HAMAP rule MF_03034
General rule information
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| Accession | MF_03034 |
| Dates | 15-APR-2009 (Created)
3-MAY-2022 (Last updated, Version 9) |
| Name | TRBP2 |
| Scope(s) |
Eukaryota Vertebrata |
| Template(s) | Q15633 (TRBP2_HUMAN); P97473 (TRBP2_MOUSE); [ Recover all ] |
| Triggered by |
HAMAP; MF_03034 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRBP2 |
| Protein name | RecName: Full=RISC-loading complex subunit @gn(TARBP2); |
| Gene name | Name=TARBP2; |
Comments
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| FUNCTION | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Within the RLC/miRLC, @gn(DICER1) and @gn(TARBP2) are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto @gn(AGO2). @gn(AGO2) bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from @gn(DICER1) and @gn(TARBP2). May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by @gn(DICER1). |
| case <OC:Mammalia> | |
| SUBUNIT | Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). |
| else | |
| SUBUNIT | Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Note that the trimeric RLC/miRLC is also referred to as RISC. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the TARBP2 family. |
Keywords
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| Cytoplasm | |
| RNA-binding | |
| RNA-mediated gene silencing | |
| Translation regulation | |
| case <OC:Mammalia> | |
| Nucleus | |
| end case | |
Gene Ontology
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| GO:0035197; Molecular function:siRNA binding |
| GO:0035198; Molecular function:miRNA binding |
| GO:0042803; Molecular function:protein homodimerization activity |
| GO:0030422; Biological process:siRNA processing |
| GO:0098795; Biological process:global gene silencing by mRNA cleavage |
| GO:0031054; Biological process:pre-miRNA processing |
| GO:0070922; Biological process:RISC complex assembly |
| GO:0016442; Cellular component:RISC complex |
Cross-references
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Features
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| From: TRBP2_HUMAN (Q15633) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Mammalia> | ||||||||||||
| REGION | 22 | 105 | /note="Sufficient for interaction with PRKRA" | |||||||||
| REGION | 152 | 234 | /note="Sufficient for interaction with PRKRA" | |||||||||
| REGION | 228 | 366 | /note="Sufficient for interaction with DICER1" | |||||||||
| REGION | 287 | 366 | /note="Sufficient for interaction with PRKRA" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 319-366 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |