HAMAP rule MF_03037
General rule information
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| Accession | MF_03037 |
| Dates | 20-JUL-2009 (Created)
28-JUN-2024 (Last updated, Version 7) |
| Name | ciao1 |
| Scope(s) |
Eukaryota |
| Template(s) | O76071 (CIAO1_HUMAN); Q05583 (CIAO1_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CIAO1 |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1; AltName: Full=WD repeat-containing protein 39; |
| else case <OC:Vertebrata> | |
| Protein name | RecName: Full=Probable cytosolic iron-sulfur protein assembly protein @gn(CIAO1); AltName: Full=WD repeat-containing protein 39; |
| else case <OC:Arthropoda> | |
| Protein name | RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1; |
| else case <OC:Fungi> | |
| Protein name | RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1; |
| else | |
| Protein name | RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=CIAO1; |
| else case <OC:Arthropoda> | |
| Gene name | Name=Ciao1; |
| else case <OC:Fungi> | |
| Gene name | Name=CIA1; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
| else case <OC:Vertebrata> | |
| FUNCTION | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. |
| else | |
| FUNCTION | Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A. |
| else case <OC:Vertebrata> | |
| SUBUNIT | Component of the CIA complex. |
| else case <OC:Saccharomycetes> | |
| SUBUNIT | Interacts with @gn(NAR1). |
| end case | |
| case <OC:Saccharomycetes> | |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus. |
| end case | |
| SIMILARITY | Belongs to the WD repeat CIA1 family. |
Keywords
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| case <OC:Mammalia> | |
| Chromosome partition | |
| end case | |
| case <OC:Saccharomycetes> | |
| Cytoplasm | |
| Nucleus | |
| end case | |
Gene Ontology
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| case <OCellular component:Mammalia> | |
| GO:0097361; Cellular component:cytosolic [4Fe-4S] assembly targeting complex | |
| GO:0071817; Cellular component:MMXD complex | |
| end case | |
| GO:0016226; Biological process:iron-sulfur cluster assembly | |
Cross-references
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| REP | Repeat_WD40; WD40; 7; |
| PROSITE | PS00678; WD_REPEATS_1; 1; |
| PROSITE | PS50082; WD_REPEATS_2; 7; |
| PROSITE | PS50294; WD_REPEATS_REGION; 1; |
| Pfam | PF00400; WD40; 7; |
Features
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Additional information
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| Size range | 313-506 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_03039 Cter: None |