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HAMAP rule MF_03044

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General rule information [?]

Accession MF_03044
Dates 26-JUN-2013 (Created)
19-NOV-2022 (Last updated, Version 12)
Name BMT2
Scope(s) Eukaryota
Template(s) P38278 (BMT2_YEAST); Q1RMZ1 (SAMTR_HUMAN); Q9W138 (SAMTR_DROME); [ Recover all ]
Triggered by HAMAP; MF_03044 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Saccharomyces>
Identifier BMT2
Protein name RecName: Full=25S rRNA (adenine(2142)-N(1))-methyltransferase;
                 EC=2.1.1.286;
AltName: Full=Base MethylTransferase of 25S RNA;
else case <OC:Fungi>
Identifier BMT2
Protein name RecName: Full=25S rRNA adenine-N(1) methyltransferase;
                 EC=2.1.1.-;
else case <OC:Metazoa>
Identifier SAMTR
Protein name RecName: Full=S-adenosylmethionine sensor upstream of mTORC1;
AltName: Full=Probable methyltransferase BMT2 homolog;
                 EC=2.1.1.-;
else
Identifier BMT2
Protein name RecName: Full=Probable methyltransferase BMT2 homolog;
                 EC=2.1.1.-;
end case
case <OC:Saccharomycotina>
Gene name Name=BMT2;
else case <OC:Vertebrata>
Gene name Name=BMT2; Synonyms=SAMTOR;
end case

Comments [?]

case <OC:Saccharomyces>
FUNCTIONS-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
CATALYTIC ACTIVITY Reaction=adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43784, Rhea:RHEA-COMP:10691, Rhea:RHEA-COMP:10692, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.286;
else case <OC:Fungi>
FUNCTIONS-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
else case <OC:Vertebrata>
FUNCTIONS-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L- methionine-dependent methyltransferase.
SUBUNITInteracts with the GATOR1 complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine.
else case <OC:Metazoa>
FUNCTIONS-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L- methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
else
FUNCTIONProbable S-adenosyl-L-methionine-dependent methyltransferase.
end case
case <OC:Fungi>
SUBCELLULAR LOCATIONNucleus, nucleolus.
end case
SIMILARITYBelongs to the BMT2 family.

Keywords [?]

case <OC:Fungi>
Nucleus
end case
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

case <OCellular component:Fungi>
GO:0005730; Cellular component:nucleolus
GO:0016433; Molecular function:rRNA (adenine) methyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0008168; Molecular function:methyltransferase activity
end case

Cross-references [?]

Pfam PF11968; DUF3321; 1;

Features [?]

From: SAMTR_HUMAN (Q1RMZ1)
Key From To Description Tag Condition FTGroup
BINDING 172 172 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 190 190 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 D

Additional information [?]

Size range 270-672 amino acids
Related rules None
Fusion Nter: None Cter: None



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