HAMAP rule MF_03045
General rule information
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Accession | MF_03045 |
Dates | 26-JUN-2013 (Created)
7-FEB-2023 (Last updated, Version 12) |
Name | DIS3L2 |
Scope(s) |
Eukaryota |
Template(s) | Q8IYB7 (DI3L2_HUMAN); Q8CI75 (DI3L2_MOUSE); P0DM58 (DI3L2_ARATH); O14040 (DI3L2_SCHPO); [ Recover all ] |
Triggered by |
HAMAP; MF_03045 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DI3L2 |
Protein name | RecName: Full=DIS3-like exonuclease 2; EC=3.1.13.-; |
case <OC:Mammalia> | |
Gene name | Name=DIS3L2; |
else case <OC:Vertebrata> | |
Gene name | Name=dis3l2; |
end case |
Comments
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case <OC:Mammalia> | |
FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
else case <OC:Vertebrata> | |
FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. |
else | |
FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. |
end case | |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
SUBCELLULAR LOCATION | Cytoplasm. Cytoplasm, P-body. |
case <OC:Vertebrata> | |
DOMAIN | Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. |
end case | |
SIMILARITY | Belongs to the RNR ribonuclease family. DIS3L2 subfamily. |
Keywords
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Cytoplasm | |
Exonuclease | |
Hydrolase | |
Magnesium | |
Manganese | |
Metal-binding | |
Nuclease | |
RNA-binding | |
case <OC:Vertebrata> | |
Cell cycle | |
Cell division | |
Mitosis | |
end case |
Gene Ontology
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GO:0005737; Cellular component:cytoplasm | |
GO:0000932; Cellular component:P-body | |
GO:0000175; Molecular function:3'-5'-RNA exonuclease activity | |
GO:0000291; Biological process:nuclear-transcribed mRNA catabolic process, exonucleolytic | |
GO:1990074; Biological process:polyuridylation-dependent mRNA catabolic process | |
case <OCellular component:Vertebrata> | |
GO:0010587; Biological process:miRNA catabolic process | |
end case |
Cross-references
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Features
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From: DI3L2_MOUSE (Q8CI75) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
SITE | 389 | 389 | /note="Important for catalytic activity" | D | ||||||||
BINDING | 381 | 381 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 390 | 390 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D |
Additional information
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Size range | 811-1426 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |