HAMAP rule MF_03052
General rule information
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| Accession | MF_03052 |
| Dates | 6-MAR-2009 (Created)
28-JUN-2024 (Last updated, Version 10) |
| Name | MOC2B |
| Scope(s) |
Eukaryota |
| Template(s) | O96007 (MOC2B_HUMAN); Q9Y8C1 (MOC2B_EMENI); [ Recover all ] |
| Triggered by |
HAMAP; MF_03052 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MOC2B |
| Protein name | RecName: Full=Molybdopterin synthase catalytic subunit; EC=2.8.1.12; AltName: Full=Molybdenum cofactor synthesis protein 2 large subunit; AltName: Full=Molybdenum cofactor synthesis protein 2B; Short=MOCS2B; |
| case <OC:Pezizomycotina> | |
| Protein name | + AltName: Full=Common component for nitrate reductase and xanthine dehydrogenase protein H; |
| end case | |
| case <OC:Pezizomycotina> | |
| Gene name | Name=cnxH; |
| else case <OC:Vertebrata> | |
| Gene name | Name=MOCS2; |
| else case <OC:Insecta> | |
| Gene name | Name=Mocs2; |
| end case | |
Comments
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| FUNCTION | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
| CATALYTIC ACTIVITY | Reaction=2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin; Xref=Rhea:RHEA:26333, Rhea:RHEA-COMP:12160, Rhea:RHEA-COMP:12202, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58698, ChEBI:CHEBI:59648, ChEBI:CHEBI:90619, ChEBI:CHEBI:90778; EC=2.8.1.12; |
| PATHWAY | Cofactor biosynthesis; molybdopterin biosynthesis. |
| SUBUNIT | Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. |
| case <OC:Vertebrata> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OC:Mammalia> | |
| MISCELLANEOUS | This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame. |
| else case <OC:Vertebrata> or <OC:Insecta> | |
| MISCELLANEOUS | This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A). |
| end case | |
| SIMILARITY | Belongs to the MoaE family. MOCS2B subfamily. |
Keywords
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Gene Ontology
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| GO:0030366; Molecular function:molybdopterin synthase activity | |
| GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process | |
| GO:1990140; Cellular component:molybdopterin synthase complex | |
| case not <OCellular component:Vertebrata> | |
| GO:0005737; Cellular component:cytoplasm | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005829; Cellular component:cytosol | |
| end case | |
Cross-references
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| Pfam | PF02391; MoaE; 1; |
Features
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| From: MOC2B_HUMAN (O96007) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 143 | 144 | /ligand="substrate" | [HF]-R | ||||||||
| BINDING | 166 | 168 | /ligand="substrate" | K-x-E | ||||||||
| BINDING | 159 | 159 | /ligand="substrate" | K | ||||||||
Additional information
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| Size range | 154-372 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |