HAMAP rule MF_03054
General rule information
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| Accession | MF_03054 |
| Dates | 26-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 5) |
| Name | CTU2 |
| Scope(s) |
Eukaryota |
| Template(s) | Q2VPK5 (CTU2_HUMAN); P53923 (CTU2_YEAST); Q9UUC7 (CTU2_SCHPO); [ Recover all ] |
| Triggered by |
HAMAP; MF_03054 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CTU2 |
| Protein name | RecName: Full=Cytoplasmic tRNA 2-thiolation protein 2; |
| case <OC:Caenorhabditis> | |
| Protein name | + AltName: Full=Thiolation of uridine in tRNA protein 2; |
| else case <OC:Saccharomyces> | |
| Protein name | + AltName: Full=Thiolation of uridine in cytoplasmic tRNA protein 2; + AltName: Full=Needs CLA4 to survive protein 2; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=CTU2; Synonyms=NCS2; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=tut-2; |
| else case <OC:Saccharomyces> | |
| Gene name | Name=NCS2; Synonyms=CTU2, TUC2; |
| else case <OC:Fungi> | |
| Gene name | Name=NCS2; Synonyms=CTU2; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(CTU1)/@gn(ATPBD3) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. |
| else case <OC:Caenorhabditis> | |
| FUNCTION | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position. |
| else case <OC:Fungi> | |
| FUNCTION | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. |
| else | |
| FUNCTION | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6)/@gn(CTU1) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. |
| end case | |
| PATHWAY | tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. |
| case <OC:Mammalia> | |
| SUBUNIT | Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. |
| else case <OC:Saccharomyces> | |
| SUBUNIT | Interacts with NCS6 and URM1. May act by forming a heterodimer with NCS6. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the CTU2/NCS2 family. |
Keywords
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Gene Ontology
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| GO:0016779; Molecular function:nucleotidyltransferase activity |
| GO:0002098; Biological process:tRNA wobble uridine modification |
| GO:0032447; Biological process:protein urmylation |
| GO:0034227; Biological process:tRNA thio-modification |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01171; ATP_bind_3; 1; |
Features
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Additional information
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| Size range | 325-687 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |