HAMAP rule MF_03056
General rule information
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| Accession | MF_03056 |
| Dates | 13-MAR-2009 (Created)
23-MAY-2024 (Last updated, Version 6) |
| Name | TRM82 |
| Scope(s) |
Eukaryota |
| Template(s) | P57081 (WDR4_HUMAN); Q03774 (TRM82_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03056 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Fungi> | |
| Identifier | TRM82 |
| Protein name | RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit AltName: Full=Transfer RNA methyltransferase 82; |
| else case <OC:Insecta> | |
| Identifier | WUHO |
| Protein name | RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit |
| else case <OC:Vertebrata> or <OC:Dictyostelium> | |
| Identifier | WDR4 |
| Protein name | RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit AltName: Full=WD repeat-containing protein 4; |
| else | |
| Identifier | WDR4 |
| Protein name | RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; AltName: Full=WD repeat-containing protein 4 homolog; |
| end case | |
| case <OC:Vertebrata> or <OC:Dictyostelium> | |
| Gene name | Name=WDR4; |
| else case <OC:Fungi> | |
| Gene name | Name=TRM82; |
| else case <OC:Insecta> | |
| Gene name | Name=wuho; |
| end case | |
Comments
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| case <OC:Drosophilidae> | |
| FUNCTION | Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis. |
| else case <OC:Saccharomyces> | |
| FUNCTION | Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
| else | |
| FUNCTION | Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
| end case | |
| PATHWAY | tRNA modification; N(7)-methylguanine-tRNA biosynthesis. |
| case <OC:Vertebrata> or <OC:Dictyostelium> | |
| SUBUNIT | Forms a heterodimer with the catalytic subunit @gn(METTL1). |
| else case <OC:Fungi> | |
| SUBUNIT | Forms a heterodimer with the catalytic subunit @gn(TRM8). |
| else | |
| SUBUNIT | Forms a heterodimer with the catalytic subunit. |
| end case | |
| case <OC:Drosophilidae> | |
| SUBCELLULAR LOCATION | Nucleus. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes. |
| else | |
| SUBCELLULAR LOCATION | Nucleus. |
| end case | |
| SIMILARITY | Belongs to the WD repeat TRM82 family. |
Keywords
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| Nucleus | |
| Repeat | |
| tRNA processing | |
| WD repeat | |
| case <OC:Drosophilidae> | |
| Developmental protein | |
| Differentiation | |
| Oogenesis | |
| Spermatogenesis | |
| end case | |
Gene Ontology
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| GO:0005634; Cellular component:nucleus | |
| GO:0106004; Biological process:tRNA (guanine-N7)-methylation | |
| case <OCellular component:Drosophilidae> | |
| GO:0007283; Biological process:spermatogenesis | |
| GO:0048477; Biological process:oogenesis | |
| end case | |
Cross-references
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| REP | Repeat_WD40; WD40; 2-7; |
| PROSITE | PS00678; WD_REPEATS_1; 1; |
| PROSITE | PS50082; WD_REPEATS_2; 1; |
| PROSITE | PS50294; WD_REPEATS_REGION; 1; |
| Pfam | PF00400; WD40; 1; |
Features
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| From: TRM82_YEAST (Q03774) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Saccharomyces> | ||||||||||||
| REPEAT | 1 | 47 | /note="WD 1" | |||||||||
| REPEAT | 48 | 99 | /note="WD 2" | |||||||||
| REPEAT | 100 | 147 | /note="WD 3" | |||||||||
| REPEAT | 148 | 192 | /note="WD 4" | |||||||||
| REPEAT | 193 | 237 | /note="WD 5" | |||||||||
| REPEAT | 238 | 279 | /note="WD 6" | |||||||||
| REPEAT | 308 | 354 | /note="WD 7" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 340-569 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |