HAMAP rule MF_03058
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03058 |
| Accession | MF_03058 |
| Dates | 3-JUN-2009 (Created)
20-NOV-2019 (Last updated, Version 6) |
| Name | VMA21 |
| Scope(s) |
Eukaryota |
| Template(s) | Q3ZAQ7 (VMA21_HUMAN); P41806 (VMA21_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03058 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | VMA21 |
| case <OC:Vertebrata> or <OC:Fungi> | |
| Protein name | RecName: Full=Vacuolar ATPase assembly integral membrane protein |
| Gene name | Name=VMA21; |
| else | |
| Protein name | RecName: Full=Vacuolar ATPase assembly integral membrane protein VMA21 homolog; |
| end case | |
Comments
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| case <OC:Saccharomyces> | |
| FUNCTION | Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29. |
| else | |
| FUNCTION | Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Associates with the V0 complex of the vacuolar ATPase (V- ATPase). |
| end case | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the VMA21 family. |
Keywords
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Gene Ontology
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| GO:0070072; Biological process:vacuolar proton-transporting V-type ATPase complex assembly |
| GO:0005789; Cellular component:endoplasmic reticulum membrane |
| GO:0012507; Cellular component:ER to Golgi transport vesicle membrane |
Cross-references
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| General | Transmembrane; -; 2; |
| ADD_TOPO_DOMAIN | Cytoplasmic; -; 2; |
| ADD_TOPO_DOMAIN | Lumenal; -; 1; |
Features
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| From: VMA21_YEAST (P41806) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Fungi> | ||||||||||||
| MOTIF | 74 | 77 | /note="Prevents secretion from ER" | K-K-x-x | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 72-127 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |