HAMAP rule MF_03060
General rule information
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| Accession | MF_03060 |
| Dates | 5-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 6) |
| Name | Draxin |
| Scope(s) |
Eukaryota Vertebrata |
| Template(s) | Q6PAL1 (DRAXI_MOUSE); B6ZI38 (DRAXI_CHICK); [ Recover all ] |
| Triggered by |
HAMAP; MF_03060 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DRAXI |
| Protein name | RecName: Full=Draxin; AltName: Full=Dorsal inhibitory axon guidance protein; AltName: Full=Dorsal repulsive axon guidance protein; |
| Gene name | Name=DRAXIN; |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| SUBUNIT | Interacts with LRP6. |
| else | |
| FUNCTION | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. |
| end case | |
| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the draxin family. |
Keywords
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| Developmental protein | |
| Secreted | |
| case <OC:Mammalia> | |
| Wnt signaling pathway | |
| end case | |
Gene Ontology
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| GO:0005576; Cellular component:extracellular region | |
| GO:0007411; Biological process:axon guidance | |
| GO:0021516; Biological process:dorsal spinal cord development | |
| GO:0021528; Biological process:commissural neuron differentiation in spinal cord | |
| GO:0030900; Biological process:forebrain development | |
| case <OCellular component:Mammalia> | |
| GO:0090090; Biological process:negative regulation of canonical Wnt signaling pathway | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 326-382 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |