HAMAP rule MF_03064
General rule information
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| Accession | MF_03064 |
| Dates | 3-JUN-2009 (Created)
29-SEP-2022 (Last updated, Version 11) |
| Name | SLC25A38 |
| Scope(s) |
Eukaryota |
| Template(s) | Q96DW6 (S2538_HUMAN); Q07534 (S2538_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03064 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | S2538 |
| case <OC:Vertebrata> | |
| Protein name | RecName: Full=Mitochondrial glycine transporter; AltName: Full=Solute carrier family 25 member 38; |
| Gene name | Name=SLC25A38; |
| else | |
| Protein name | RecName: Full=Mitochondrial glycine transporter; AltName: Full=Solute carrier family 25 member 38 homolog; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. |
| else | |
| FUNCTION | Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715, ChEBI:CHEBI:57305; |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. |
Keywords
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| Membrane |
| Mitochondrion |
| Mitochondrion inner membrane |
| Repeat |
| Transmembrane |
| Transmembrane helix |
| Transport |
Gene Ontology
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| GO:0015187; Molecular function:glycine transmembrane transporter activity | |
| GO:1904983; Biological process:glycine import into mitochondrion | |
| case <OCellular component:Vertebrata> | |
| GO:0030218; Biological process:erythrocyte differentiation | |
| end case | |
| GO:0016020; Cellular component:membrane | |
| GO:0005743; Cellular component:mitochondrial inner membrane | |
Cross-references
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| PROSITE | PS50920; SOLCAR; 3; |
| Pfam | PF00153; Mito_carr; 3; |
| PRINTS | PR00926; MITOCARRIER; 1; |
| General | Transmembrane; -; 0-6; |
Features
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| From: S2538_HUMAN (Q96DW6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 31 | 56 | /note="Helical; Name=1" | |||||||||
| TRANSMEM | 89 | 115 | /note="Helical; Name=2" | |||||||||
| TRANSMEM | 127 | 152 | /note="Helical; Name=3" | |||||||||
| TRANSMEM | 180 | 203 | /note="Helical; Name=4" | |||||||||
| TRANSMEM | 219 | 245 | /note="Helical; Name=5" | |||||||||
| TRANSMEM | 274 | 292 | /note="Helical; Name=6" | |||||||||
Additional information
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| Size range | 287-362 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |