HAMAP rule MF_03068
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03068 |
| Accession | MF_03068 |
| Dates | 19-FEB-2009 (Created)
2-SEP-2024 (Last updated, Version 5) |
| Name | DHX29 |
| Scope(s) |
Eukaryota Vertebrata |
| Template(s) | Q7Z478 (DHX29_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03068 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DHX29 |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=ATP-dependent RNA helicase DHX29; EC=3.6.4.13; AltName: Full=DEAH box protein 29; |
| else | |
| Protein name | RecName: Full=ATP-dependent RNA helicase EC=3.6.4.13; AltName: Full=DEAH box protein 29; |
| end case | |
| Gene name | Name=DHX29; |
Comments
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| FUNCTION | ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. |
| case <OC:Mammalia> | |
| SUBUNIT | Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. |
| else | |
| SUBUNIT | Part of the 43S pre-initiation complex (PIC). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DEAD box helicase family. DEAH subfamily. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0003724; Molecular function:RNA helicase activity |
| GO:0045948; Biological process:positive regulation of translational initiation |
Cross-references
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| PROSITE | PS00690; DEAH_ATP_HELICASE; 1; |
| PROSITE | PS51192; HELICASE_ATP_BIND_1; 1; |
| PROSITE | PS51194; HELICASE_CTER; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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Additional information
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| Size range | 1300-1400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |