HAMAP rule MF_03104

General rule information [?]

Accession	MF_03104
Dates	14-AUG-2009 (Created) 20-NOV-2019 (Last updated, Version 8)
Name	Mdm12
Scope(s)	Eukaryota Fungi
Template(s)	Q92328 (MDM12_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03104 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MDM12
Protein name	RecName: Full=Mitochondrial distribution and morphology protein 12; AltName: Full=Mitochondrial inheritance component ;
Gene name	Name=MDM12;

Comments [?]

FUNCTION	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta- barrel protein @gn(MDM10). The -@gn(MMM1) subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The @gn(MDM10)--@gn(MMM1) subcomplex further acts in the @gn(TOM40)-specific pathway after the action of the -@gn(MMM1) complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
case <OC:Saccharomyces>
SUBUNIT	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), and @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of @gn(MMM1) and generate a continuous hydrophobic tunnel for phospholipid trafficking. Interacts with PUF3.
else
SUBUNIT	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), and @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of @gn(MMM1) and generate a continuous hydrophobic tunnel for phospholipid trafficking.
end case
SUBCELLULAR LOCATION	Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
SIMILARITY	Belongs to the MDM12 family.

Keywords [?]

Endoplasmic reticulum

Membrane

Mitochondrion

Mitochondrion outer membrane

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane

GO:0005741; Cellular component:mitochondrial outer membrane

GO:0032865; Cellular component:ERMES complex

GO:0000002; Biological process:mitochondrial genome maintenance

GO:0045040; Biological process:protein insertion into mitochondrial outer membrane

Cross-references [?]

PROSITE

PS51847; SMP; 1;

Features [?]

Additional information [?]

Size range	239-675 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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