HAMAP rule MF_03105

General rule information [?]

Accession	MF_03105
Dates	14-AUG-2009 (Created) 29-SEP-2022 (Last updated, Version 8)
Name	Mdm34
Scope(s)	Eukaryota Fungi
Template(s)	P53083 (MDM34_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MDM34
case <OC:Saccharomyces>
Protein name	RecName: Full=Mitochondrial distribution and morphology protein 34; AltName: Full=Mitochondrial outer membrane protein MMM2;
else
Protein name	RecName: Full=Mitochondrial distribution and morphology protein 34;
end case
case <OC:Saccharomyces>
Gene name	Name=MDM34; Synonyms=MMM2;
else
Gene name	Name=MDM34;
end case

Comments [?]

FUNCTION	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta- barrel protein @gn(MDM10).
SUBUNIT	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and .
SUBCELLULAR LOCATION	Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
DOMAIN	Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
case <OC:Saccharomyces>
PTM	Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin- protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity.
end case
SIMILARITY	Belongs to the MDM34 family.

Keywords [?]

Membrane
Mitochondrion
Mitochondrion outer membrane
Transmembrane
Transmembrane beta strand
case <OC:Saccharomyces>
Ubl conjugation
end case

Gene Ontology [?]

GO:0005741; Cellular component:mitochondrial outer membrane

GO:0032865; Cellular component:ERMES complex

GO:0000002; Biological process:mitochondrial genome maintenance

Cross-references [?]

PROSITE

PS51847; SMP; 1;

Features [?]

Additional information [?]