HAMAP rule MF_03113
General rule information
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| Accession | MF_03113 |
| Dates | 12-OCT-2009 (Created)
26-FEB-2021 (Last updated, Version 5) |
| Name | Get1 |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | P53192 (GET1_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03113 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GET1 |
| case <OC:Saccharomycotina> | |
| Protein name | RecName: Full=Golgi to ER traffic protein 1; AltName: Full=Guided entry of tail-anchored proteins 1; |
| else | |
| Protein name | RecName: Full=Protein AltName: Full=Guided entry of tail-anchored proteins 1; |
| end case | |
| Gene name | Name=GET1; |
Comments
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| case <OC:Saccharomycotina> | |
| FUNCTION | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET2), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. |
| SUBUNIT | Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer. |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
| else | |
| FUNCTION | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. |
| SUBUNIT | Interacts with @gn(GET3). |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the WRB/GET1 family. |
Keywords
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| Endoplasmic reticulum | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
| case <OC:Saccharomycotina> | |
| ER-Golgi transport | |
| Golgi apparatus | |
| end case | |
Gene Ontology
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| case <OCellular component:Saccharomycotina> | |
| GO:0043529; Cellular component:GET complex | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005783; Cellular component:endoplasmic reticulum | |
| end case | |
| GO:0045048; Biological process:protein insertion into ER membrane | |
Cross-references
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| Pfam | PF04420; CHD5; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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| From: GET1_YEAST (P53192) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 1 | /note="Lumenal" | |||||||||
| TRANSMEM | 2 | 21 | /note="Helical" | |||||||||
| TOPO_DOM | 22 | 104 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 105 | 125 | /note="Helical" | |||||||||
| TOPO_DOM | 126 | 181 | /note="Lumenal" | |||||||||
| TRANSMEM | 182 | 198 | /note="Helical" | |||||||||
| TOPO_DOM | 199 | Cter | /note="Cytoplasmic" | |||||||||
Additional information
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| Size range | 170-237 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |