HAMAP rule MF_03114
General rule information
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Accession | MF_03114 |
Dates | 12-OCT-2009 (Created)
26-FEB-2021 (Last updated, Version 6) |
Name | Get2 |
Scope(s) |
Eukaryota Saccharomycotina |
Template(s) | P40056 (GET2_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03114 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GET2 |
case <OC:Saccharomyces> | |
Protein name | RecName: Full=Golgi to ER traffic protein 2; AltName: Full=Hydroxyurea resistance protein 2; AltName: Full=Required for meiotic nuclear division protein 7; |
else | |
Protein name | RecName: Full=Golgi to ER traffic protein 2; |
end case | |
case <OC:Saccharomyces> | |
Gene name | Name=GET2; Synonyms=HUR2, RMD7; |
else | |
Gene name | Name=GET2; |
end case |
Comments
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case <OC:Saccharomyces> | |
FUNCTION | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function. |
else | |
FUNCTION | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. |
end case | |
SUBUNIT | Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer. |
SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the GET2 family. |
Keywords
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Endoplasmic reticulum | |
ER-Golgi transport | |
Golgi apparatus | |
Membrane | |
Transmembrane | |
Transmembrane helix | |
Transport | |
case <FTTag:glyco> | |
Glycoprotein | |
end case |
Gene Ontology
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GO:0043529; Cellular component:GET complex |
GO:0045048; Biological process:protein insertion into ER membrane |
Cross-references
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Pfam | PF08690; GET2; 1; |
Features
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From: GET2_YEAST (P40056) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 148 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 149 | 169 | /note="Helical" | |||||||||
TOPO_DOM | 170 | 196 | /note="Lumenal" | |||||||||
TRANSMEM | 197 | 216 | /note="Helical" | |||||||||
TOPO_DOM | 217 | 263 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 264 | 284 | /note="Helical" | |||||||||
TOPO_DOM | 285 | Cter | /note="Lumenal" | |||||||||
case <OC:Saccharomyces> | ||||||||||||
CARBOHYD | 173 | 173 | /note="N-linked (GlcNAc...) asparagine" | glyco | N | |||||||
CARBOHYD | 196 | 196 | /note="N-linked (GlcNAc...) asparagine" | glyco | N | |||||||
end case |
Additional information
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Size range | 266-357 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |