HAMAP rule MF_03121
General rule information
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| Accession | MF_03121 |
| Dates | 18-JUN-2010 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | lonp2_euk |
| Scope(s) |
Eukaryota |
| Template(s) | Q86WA8 (LONP2_HUMAN); O64948 (LONP2_ARATH); Q2V573 (LONP2_PICAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03121 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LONP2 |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=Lon protease homolog 2, peroxisomal; EC=3.4.21.-; AltName: Full=Lon protease-like protein 2; Short=Lon protease 2; AltName: Full=Peroxisomal Lon protease; |
| else | |
| Protein name | RecName: Full=Lon protease homolog 2, peroxisomal; EC=3.4.21.-; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=LONP2; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. |
| SUBUNIT | Interacts with PEX5. Interacts with TYSND1. |
| else | |
| FUNCTION | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. |
| end case | |
| SUBCELLULAR LOCATION | Peroxisome matrix. |
| SIMILARITY | Belongs to the peptidase S16 family. |
Keywords
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| case <FTTag:ATP> | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
| Hydrolase | |
| Peroxisome | |
| Protease | |
| Serine protease | |
Gene Ontology
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| GO:0005782; Cellular component:peroxisomal matrix |
| GO:0005524; Molecular function:ATP binding |
| GO:0016887; Molecular function:ATP hydrolysis activity |
| GO:0004176; Molecular function:ATP-dependent peptidase activity |
| GO:0004252; Molecular function:serine-type endopeptidase activity |
| GO:0006515; Biological process:protein quality control for misfolded or incompletely synthesized proteins |
| GO:0016485; Biological process:protein processing |
| GO:0016558; Biological process:protein import into peroxisome matrix |
Cross-references
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| PROSITE | PS51787; LON_N; 1; |
| PROSITE | PS51786; LON_PROTEOLYTIC; 1; |
| PROSITE | PS01046; LON_SER; 1; |
| Pfam | PF00004; AAA; 1; |
| Pfam | PF02190; LON; 1; |
| PRINTS | PR00830; ENDOLAPTASE; 1; |
| NCBIfam | TIGR00763; lon; 1; |
Features
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| From: LONP2_HUMAN (Q86WA8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 375 | 382 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
ATP | G-P-[PT]-G-[ITV]-G-K-T | |||||||
| ACT_SITE | 743 | 743 | S | |||||||||
| ACT_SITE | 786 | 786 | K | |||||||||
| MOTIF | Cter-2 | Cter | /note="Microbody targeting signal" | |||||||||
Additional information
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| Size range | 773-1258 amino acids |
| Related rules |
MF_03120 MF_01973 |
| Fusion | Nter: None Cter: None |