Annotation rule MF_03130
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General rule information [?]

Accession MF_03130
Dates 22-OCT-2010 (Created)
13-JUL-2016 (Last updated, Version 9)
Name mec17
Scope Eukaryota
Templates Q5SQI0 (ATAT_HUMAN); Q8K341 (ATAT_MOUSE); Q6PH17 (ATAT_DANRE); Q22XZ3 (ATAT_TETTS); O45100 (ATAT1_CAEEL): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ATAT
case <OC:Vertebrata>
Protein name
RecName: Full=Alpha-tubulin N-acetyltransferase 1;
Short=Alpha-TAT;
Short=Alpha-TAT1;
Short=TAT;
EC=2.3.1.108;
AltName: Full=Acetyltransferase mec-17 homolog;
else case <OC:Caenorhabditis>
Protein name
RecName: Full=Alpha-tubulin N-acetyltransferase;
Short=Alpha-TAT;
Short=TAT;
EC=2.3.1.108;
else
Protein name
RecName: Full=Alpha-tubulin N-acetyltransferase;
Short=Alpha-TAT;
Short=TAT;
EC=2.3.1.108;
AltName: Full=Acetyltransferase mec-17 homolog;
end case
case <OC:Caenorhabditis>
Gene name
mec-17
else case <OC:Vertebrata>
Gene name
ATAT1, MEC17
end case

Comments [?]

case <OC:Mammalia>
Function Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
else case <OC:Vertebrata>
Function Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.
else case <OC:Caenorhabditis>
Function Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.
else
Function Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
end case
Catalytic activity Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.
case <OC:Mammalia>
Subunit Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
Ptm Autoacetylation strongly increases tubulin acetylation.
end case
case <OC:Vertebrata>
Subcellular location Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
end case
Similarity Belongs to the acetyltransferase ATAT1 family.

Keywords [?]

case <OC:Mammalia>
end case
case <OC:Vertebrata>
end case

Gene Ontology [?]

GO:0019799; Molecular function: tubulin N-acetyltransferase activity.
GO:0071929; Biological process: alpha-tubulin acetylation.
GO:0070507; Biological process: regulation of microtubule cytoskeleton organization.
case <OC:Metazoa> and not <OC:Placozoa> and not <OC:Porifera>
GO:0048666; Biological process: neuron development.
end case

Cross-references [?]

Pfam PF05301; Mec-17; 1;
PROSITE PS51730; GNAT_ATAT; 1; trigger=PRU00532;

Features [?]

From: ATAT_HUMAN (Q5SQI0)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     124     137       Acetyl-CoA binding     F-[YF]-x(5)-[QR]-[RK]-x-G-x-G-x  
REGION     160     169       Acetyl-CoA binding     S-x-K-[FLM]-x(2)-F-[LM]-x-K  
SITE     58     58       Crucial for catalytic activity     Q  
case <OC:Mammalia>
MOD_RES     56     56       N6-acetyllysine; by autocatalysis     K  
MOD_RES     146     146       N6-acetyllysine; by autocatalysis     K  
MOD_RES     233     233       N6-acetyllysine; by autocatalysis     K  
MOD_RES     244     244       N6-acetyllysine; by autocatalysis     K  
end case

Additional information [?]

Size range 179-483 amino acids
Related rules None
Fusion None