HAMAP rule MF_03153
General rule information
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| Accession | MF_03153 |
| Dates | 24-OCT-2011 (Created)
10-DEC-2019 (Last updated, Version 9) |
| Name | U1_C |
| Scope(s) |
Eukaryota |
| Template(s) | P09234 (RU1C_HUMAN); Q05900 (RU1C_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03153 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RU1C |
| Protein name | RecName: Full=U1 small nuclear ribonucleoprotein C; Short=U1 snRNP C; Short=U1-C; Short=U1C; |
| case <OC:Vertebrata> | |
| Gene name | Name=SNRPC; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=snRNP-U1-C; |
| else case <OC:Dictyostelia> | |
| Gene name | Name=snrpC; |
| else case <OC:Saccharomycotina> | |
| Gene name | Name=YHC1; |
| end case | |
Comments
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| case <OC:Vertebrata> or <OC:Dictyostelia> | |
| FUNCTION | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
| SUBUNIT | U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. |
| else | |
| FUNCTION | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
| SUBUNIT | U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. |
| end case | |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the U1 small nuclear ribonucleoprotein C family. |
Keywords
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Gene Ontology
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| GO:0000243; Cellular component:commitment complex |
| GO:0005685; Cellular component:U1 snRNP |
| GO:0071004; Cellular component:U2-type prespliceosome |
| GO:0003729; Molecular function:mRNA binding |
| GO:0030619; Molecular function:U1 snRNA binding |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0000395; Biological process:mRNA 5'-splice site recognition |
| GO:0000387; Biological process:spliceosomal snRNP assembly |
Cross-references
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| PROSITE | PS50171; ZF_MATRIN; 1; |
| Pfam | PF06220; zf-U1; 1; |
| PIRSF | PIRSF037969; U1_snRNP-C; 1; |
Features
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Additional information
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| Size range | 122-242 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |