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HAMAP rule MF_03164

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General rule information [?]

Accession MF_03164
Dates 13-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 12)
Name Top6A_euk
Scope(s) Eukaryota
Viridiplantae
Template(s) Q57815 (TOP6A_METJA); Q9LZ03 (TOP6A_ARATH); A2XFC1 (TOP6A_ORYSI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00132 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TOP6A
Protein name RecName: Full=DNA topoisomerase 6 subunit A;
                 EC=5.6.2.2;
Gene name Name=TOP6A;

Comments [?]

FUNCTIONComponent of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SUBUNITHomodimer. Heterotetramer of two TOP6A and two TOP6B subunits.
SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the TOP6A family.

Keywords [?]


Gene Ontology [?]

GO:0009330; Cellular component:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0005634; Cellular component:nucleus
GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0000287; Molecular function:magnesium ion binding
GO:0006265; Biological process:DNA topological change

Cross-references [?]

Pfam PF04406; TP6A_N; 1;
PRINTS PR01550; TOP6AFAMILY; 1;
PRINTS PR01552; TPISMRASE6A; 1;
PROSITE PS50324; SER_RICH; 0-unlimited;

Features [?]

From: TOP6A_METJA (Q57815)
Key From To Description Tag Condition FTGroup
ACT_SITE 103 103 /note="Nucleophile" Y
BINDING 197 197 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E
BINDING 249 249 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D

Additional information [?]

Size range 340-453 amino acids
Related rules None
Fusion Nter: None Cter: None



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