HAMAP rule MF_03187

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03187
Accession	MF_03187
Dates	13-FEB-2015 (Created) 20-NOV-2019 (Last updated, Version 4)
Name	Methyltr_EFM5
Scope(s)	Eukaryota
Template(s)	P53200 (EFM5_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03187 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier	EFMT1
Protein name	RecName: Full=EEF1A lysine methyltransferase 1; EC=2.1.1.-; AltName: Full=N(6)-adenine-specific DNA methyltransferase 2; AltName: Full=Protein-lysine N-methyltransferase N6AMT2;
Gene name	Name=EEF1AKMT1; Synonyms=N6AMT2;
else case <OC:Fungi>
Identifier	EFM5
Protein name	RecName: Full=Protein-lysine N-methyltransferase ; EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 5;
Gene name	Name=EFM5;
else
Protein name	RecName: Full=Protein-lysine N-methyltransferase ; EC=2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTION	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
else case <OC:Fungi>
FUNCTION	S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates elongation factor 1-alpha at 'Lys- 79'.
else
FUNCTION	S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
case <OC:Vertebrata>
CAUTION	Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.
end case

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

GO:0016279; Molecular function:protein-lysine N-methyltransferase activity

GO:0018022; Biological process:peptidyl-lysine methylation

Cross-references [?]

Pfam	PF10237; N6-adenineMlase; 1;

Features [?]

Additional information [?]