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HAMAP rule MF_03187

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General rule information [?]

Accession MF_03187
Dates 13-FEB-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Methyltr_EFM5
Scope(s) Eukaryota
Template(s) P53200 (EFM5_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03187 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier EFMT1
Protein name RecName: Full=EEF1A lysine methyltransferase 1;
                 EC=2.1.1.-;
AltName: Full=N(6)-adenine-specific DNA methyltransferase 2;
AltName: Full=Protein-lysine N-methyltransferase N6AMT2;
Gene name Name=EEF1AKMT1; Synonyms=N6AMT2;
else case <OC:Fungi>
Identifier EFM5
Protein name RecName: Full=Protein-lysine N-methyltransferase ;
                 EC=2.1.1.-;
AltName: Full=Elongation factor methyltransferase 5;
Gene name Name=EFM5;
else
Protein name RecName: Full=Protein-lysine N-methyltransferase ;
                 EC=2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONProtein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
else case <OC:Fungi>
FUNCTIONS-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates elongation factor 1-alpha at 'Lys- 79'.
else
FUNCTIONS-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
case <OC:Vertebrata>
CAUTIONWas originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.
end case

Keywords [?]


Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0016279; Molecular function:protein-lysine N-methyltransferase activity
GO:0018022; Biological process:peptidyl-lysine methylation

Cross-references [?]

Pfam PF10237; N6-adenineMlase; 1;

Features [?]


Additional information [?]

Size range 205-277 amino acids
Related rules None
Fusion Nter: None Cter: None



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