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HAMAP rule MF_03188

General rule information [?]

Accession	MF_03188
Dates	17-FEB-2015 (Created) 20-NOV-2019 (Last updated, Version 4)
Name	Methyltr_EFM4
Scope(s)	Eukaryota
Template(s)	P40516 (EFM4_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03188 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier	EFMT2
Protein name	RecName: Full=EEF1A lysine methyltransferase 2; EC=2.1.1.-; AltName: Full=Methyltransferase-like protein 10; AltName: Full=Protein-lysine N-methyltransferase METTL10;
Gene name	Name=EEF1AKMT2; Synonyms=METTL10;
else case <OC:Fungi>
Identifier	EFM4
Protein name	RecName: Full=Protein-lysine N-methyltransferase ; EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 4;
Gene name	Name=EFM4;
else
Protein name	RecName: Full=Protein-lysine N-methyltransferase ; EC=2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTION	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
SUBCELLULAR LOCATION	Cytoplasm. Nucleus.
else case <OC:Fungi>
FUNCTION	S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.
SUBCELLULAR LOCATION	Cytoplasm.
else
FUNCTION	S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha.
SUBCELLULAR LOCATION	Cytoplasm.
end case
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Vertebrata>
GO:0005634; Cellular component:nucleus
end case
case <OCellular component:Fungi>
GO:0016192; Biological process:vesicle-mediated transport
end case
GO:0005737; Cellular component:cytoplasm
GO:0016279; Molecular function:protein-lysine N-methyltransferase activity
GO:0018022; Biological process:peptidyl-lysine methylation

Cross-references [?]

Pfam	PF13847; Methyltransf_31; 1;

Features [?]

Additional information [?]