HAMAP rule MF_03198
General rule information
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| Accession | MF_03198 |
| Dates | 7-OCT-2015 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | Methyltr_EFM6 |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | P53970 (EFM6_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03198 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EFM6 |
| Protein name | RecName: Full=Protein-lysine N-methyltransferase EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 6; |
| Gene name | Name=EFM6; |
Comments
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| FUNCTION | S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily. |
Keywords
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Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
| GO:0016279; Molecular function:protein-lysine N-methyltransferase activity |
| GO:0018022; Biological process:peptidyl-lysine methylation |
Cross-references
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| Pfam | PF10294; Methyltransf_16; 1; |
Features
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| From: EFM6_YEAST (P53970) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 87 | 89 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-[SA]-G | ||||||||
| BINDING | 51 | 51 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
| BINDING | 115 | 115 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 143 | 143 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
| BINDING | 169 | 169 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[AGS] | ||||||||
Additional information
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| Size range | 221-338 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |