HAMAP rule MF_03226
General rule information
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| Accession | MF_03226 |
| Dates | 19-DEC-2018 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | YJU2 |
| Scope(s) |
Eukaryota |
| Template(s) | P28320 (YJU2_YEAST); Q9BW85 (YJU2_HUMAN); A8WHR3 (YJU2_DANRE); Q9P7C5 (YJU2_SCHPO); [ Recover all ] |
| Triggered by |
HAMAP; MF_03226 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YJU2 |
| Protein name | RecName: Full=Splicing factor YJU2; |
| case <OC:Saccharomycetales> or <OC:Vertebrata> | |
| Gene name | Name=YJU2; |
| end case | |
Comments
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| case <OC:Saccharomycetales> | |
| FUNCTION | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'- intermediates. Further stabilizes spliceosome conformation for 3'- splice site docking (via C-terminus) promoting exon ligation. |
| else case <OC:Vertebrata> | |
| FUNCTION | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. |
| else | |
| FUNCTION | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. |
| end case | |
| SUBUNIT | Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the CWC16 family. YJU2 subfamily. |
Keywords
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| Nucleus | |
| Spliceosome | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0071006; Cellular component:U2-type catalytic step 1 spliceosome | |
| GO:0000349; Biological process:generation of catalytic spliceosome for first transesterification step | |
| case <OCellular component:Saccharomycetales> | |
| GO:0071007; Cellular component:U2-type catalytic step 2 spliceosome | |
| GO:0000350; Biological process:generation of catalytic spliceosome for second transesterification step | |
| end case | |
Cross-references
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| Pfam | PF04502; DUF572; 1; |
Features
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| From: YJU2_YEAST (P28320) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 51 | 51 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 54 | 54 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 88 | 88 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 91 | 91 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 270-345 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |