HAMAP rule MF_04034

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_04034
Accession	MF_04034
Dates	5-SEP-2016 (Created) 11-JUL-2023 (Last updated, Version 6)
Name	HSV_GL_alphagamma
Scope(s)	Viruses Herpesviridae
Template(s)	P10185 (GL_HHV11); P03212 (GL_EBVB9); F5HDB7 (GL_HHV8P); [ Recover all ]
Triggered by	HAMAP; MF_04034 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GL
Protein name	RecName: Full=Envelope glycoprotein L; Short=gL;
Gene name	Name=gL;

Comments [?]

FUNCTION	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
SUBUNIT	Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
SUBCELLULAR LOCATION	Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.

Keywords [?]

Gene Ontology [?]

GO:0020002; Cellular component:host cell plasma membrane

GO:0019031; Cellular component:viral envelope

GO:0055036; Cellular component:virion membrane

GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Cross-references [?]

Features [?]

From: GL_HHV11 (P10185)

Key

From

Description

Tag

Condition

FTGroup

REGION

161

/note="Interaction with gH"

Additional information [?]