HAMAP rule MF_04035
General rule information
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Accession | MF_04035 |
Dates | 30-AUG-2016 (Created)
29-SEP-2022 (Last updated, Version 4) |
Name | HSV_GM |
Scope(s) |
Viruses Herpesviridae |
Template(s) | P04288 (GM_HHV11); P16733 (GM_HCMVA); [ Recover all ] |
Triggered by |
HAMAP; MF_04035 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GM |
Protein name | RecName: Full=Envelope glycoprotein M; Short=gM; |
Gene name | Name=gM; |
Comments
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FUNCTION | Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network. |
SUBUNIT | Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex. |
SUBCELLULAR LOCATION | Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs. |
SIMILARITY | Belongs to the herpesviridae glycoprotein M family. |
Keywords
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Disulfide bond |
Glycoprotein |
Host endosome |
Host Golgi apparatus |
Host membrane |
Host nucleus |
Membrane |
Transmembrane |
Transmembrane helix |
Viral envelope protein |
Virion |
Gene Ontology
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GO:0044175; Cellular component:host cell endosome membrane |
GO:0044178; Cellular component:host cell Golgi membrane |
GO:0044201; Cellular component:host cell nuclear inner membrane |
GO:0016020; Cellular component:membrane |
GO:0019031; Cellular component:viral envelope |
GO:0055036; Cellular component:virion membrane |
Cross-references
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Pfam | PF01528; Herpes_glycop; 1; |
PRINTS | PR00333; HSVINTEGRLMP; 1; |
General | Transmembrane; -; 8; |
ADD_TOPO_DOMAIN | Intravirion; -; 5; |
ADD_TOPO_DOMAIN | Virion_surface; -; 4; |
Features
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From: GM_HHV11 (P04288) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 59 | 59 | /note="Interchain (with gN)" | C |
Additional information
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Size range | 344-473 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |