HAMAP rule MF_04037
General rule information
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| Accession | MF_04037 |
| Dates | 15-SEP-2016 (Created)
29-SEP-2022 (Last updated, Version 7) |
| Name | HSV_GN |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | O09800 (GN_HHV11); P16795 (GN_HCMVA); P0C764 (GN_VZVO); [ Recover all ] |
| Triggered by |
HAMAP; MF_04037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GN |
| Protein name | RecName: Full=Envelope glycoprotein N; |
| Gene name | Name=gN; |
Comments
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| FUNCTION | Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis. |
| SUBUNIT | Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex. |
| SUBCELLULAR LOCATION | Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Host Golgi apparatus, host trans-Golgi network. Note=When coexpressed with gM, localizes in the host trans-Golgi network. |
| SIMILARITY | Belongs to the herpesviridae glycoprotein N family. |
Keywords
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| Disulfide bond |
| Host Golgi apparatus |
| Host membrane |
| Membrane |
| Transmembrane |
| Transmembrane helix |
| Viral envelope protein |
| Virion |
Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0055036; Cellular component:virion membrane |
Cross-references
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| Pfam | PF03554; Herpes_UL73; 1; |
| Pfam | PF12522; UL73_N; 1; |
| Pfam | PF05702; Herpes_UL49_5; 1; |
| PIRSF | PIRSF038075; Herpes_UL49A_env; 1; |
| ADD_TOPO_DOMAIN | Virion_surface; -; 1; |
| ADD_TOPO_DOMAIN | Intravirion; -; 1; |
| General | Transmembrane; -; 1; |
| General | Signal; -; 0-1; |
Features
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| From: GN_HHV11 (O09800) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case not <Feature:Transmembrane==1> | ||||||||||||
| TOPO_DOM | Nter | 55 | /note="Virion surface" | |||||||||
| TRANSMEM | 56 | 76 | /note="Helical" | |||||||||
| TOPO_DOM | 77 | Cter | /note="Intravirion" | |||||||||
| end case | ||||||||||||
| DISULFID | 46 | 46 | /note="Interchain (with gM)" | C | ||||||||
Additional information
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| Size range | 84-171 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |