HAMAP rule MF_04109
General rule information
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| Accession | MF_04109 |
| Dates | 2-NOV-2016 (Created)
23-AUG-2022 (Last updated, Version 7) |
| Name | ENDOLYSIN_LAMBDA |
| Scope(s) |
Viruses Caudoviricetes |
| Template(s) | P03706 (ENLYS_LAMBD); [ Recover all ] |
| Triggered by |
HAMAP; MF_04109 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ENLYS |
| Protein name | RecName: Full=Endolysin; EC=4.2.2.n2; AltName: Full=Transglycosylase; AltName: Full=Lysozyme; AltName: Full=Lysis protein; |
Comments
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| FUNCTION | Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer. |
| CATALYTIC ACTIVITY | Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2; |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane. |
| SIMILARITY | Belongs to the glycosyl hydrolase 24 family. |
Keywords
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| Antimicrobial |
| Bacteriolytic enzyme |
| Cytolysis |
| Host cell lysis by virus |
| Host cytoplasm |
| Lyase |
| Viral release from host cell |
Gene Ontology
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| GO:0003796; Molecular function:lysozyme activity |
| GO:0016829; Molecular function:lyase activity |
| GO:0044659; Biological process:viral release from host cell by cytolysis |
| GO:0009253; Biological process:peptidoglycan catabolic process |
Cross-references
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| Pfam | PF00959; Phage_lysozyme; 1; |
Features
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| From: ENLYS_LAMBD (P03706) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 19 | 19 | E | |||||||||
Additional information
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| Size range | 153-181 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |