HAMAP proteomes
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)

General information

Species:  Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Species code: BORBU
Taxonomy: Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella (TaxID: 224326) [NEWT/ NCBI]
Description: Borreliae, the causative agent of Lyme disease, are obligatorily bound to their host organisms for survival. It is a Spirochetes, a spiral-shaped bacterium. Highly specialized, motile, with two membranes, it lives primarily as an extracellular pathogen. During their life cycle they switch from the invertebrate host tick (Ixodes spec.) to various vertebrate hosts via a tick bite. It seems that Borellia have three indispensable components; a chromosome, a circular plasmid of approximately 26 kb and a linear plasmid of approximately 54 kb, each species can also contain many other plasmids. The range of vertebrates and invertebrates used as hosts is thought to be mediated by factors encoded mainly on a large number of different plasmids found in Borreliae genomes. These plasmids are characterized by their wealth of paralogous genes. It is thought that Borreliae plasmids are not stable and are frequently rearranged leading to differing plasmid content within a species. The chromosome is also involved in fission/fusion events, and the right end of the chromosome of B. burgdorferi strains is variable due to its ability to catch plasmids. During passage plasmids can be lost due to the lack of selection pressure, which can be accompanied by the inability of Borreliae to prosper in the host. It was first isolated in the early 1980s from the midgut of Ixodes ticks.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2

Genome(s) sequenced

Strain:    ATCC 35210 / B31 / CIP 102532 / DSM 4680
Genome structure:
• Chromosome EMBL accession number AE000783 (linear; 910,724 bp) (download entry)
• Plasmid lp54 EMBL accession number AE000790 (linear; 53,657 bp) (download entry)
• Plasmid cp26 EMBL accession number AE000792 (circular; 26,498 bp) (download entry)
• Plasmid cp9 EMBL accession number AE000791 (circular; 9,386 bp) (download entry)
• Plasmid lp17 EMBL accession number AE000793 (linear; 16,821 bp) (download entry)
• Plasmid lp25 EMBL accession number AE000785 (linear; 24,177 bp) (download entry)
• Plasmid lp28-1 EMBL accession number AE000794 (linear; 28,155 bp) (download entry)
• Plasmid lp28-2 EMBL accession number AE000786 (linear; 29,766 bp) (download entry)
• Plasmid lp28-3 EMBL accession number AE000784 (linear; 28,601 bp) (download entry)
• Plasmid lp28-4 EMBL accession number AE000789 (linear; 27,323 bp) (download entry)
• Plasmid lp38 EMBL accession number AE000787 (linear; 38,829 bp) (download entry)
• Plasmid lp36 EMBL accession number AE000788 (linear; 36,849 bp) (download entry)
• Plasmid lp5 EMBL accession number AE001583 (linear; 5,228 bp) (download entry)
• Plasmid lp21 EMBL accession number AE001582 (linear; 18,777 bp) (download entry)
• Plasmid lp56 EMBL accession number AE001584 (linear; 52,971 bp) (download entry)
• Plasmid cp32-1 EMBL accession number AE001575 (circular; 30,750 bp) (download entry)
• Plasmid cp32-3 EMBL accession number AE001576 (circular; 30,223 bp) (download entry)
• Plasmid cp32-4 EMBL accession number AE001577 (circular; 30,299 bp) (download entry)
• Plasmid cp32-6 EMBL accession number AE001578 (circular; 29,838 bp) (download entry)
• Plasmid cp32-7 EMBL accession number AE001579 (circular; 30,800 bp) (download entry)
• Plasmid cp32-8 EMBL accession number AE001580 (circular; 30,885 bp) (download entry)
• Plasmid cp32-9 EMBL accession number AE001581 (circular; 30,651 bp) (download entry)
[1] Pubmed=9403685;
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. ;
"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
Nature 390:580-586(1997).
[2] Pubmed=10672174;
Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P., Lathigra R., Sutton G.G., Peterson J.D., Dodson R.J., Haft D.H., Hickey E.K., Gwinn M.L., White O., Fraser C.M. ;
"A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi.";
Mol. Microbiol. 35:490-516(2000).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Borrelia&GLspecies=burgdorferi&GLstrain=B31
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid224326%5Borgn%5D
PEDANT: http://pedant.helmholtz-muenchen.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p3_Bor_burgd