HAMAP rule MF_00001
General rule information
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Accession | MF_00001 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36) |
Name | Asp_carb_tr |
Scope(s) |
Bacteria Archaea |
Template(s) | P0A786 (PYRB_ECOLI); P05654 (PYRB_BACSU); Q58976 (PYRB_METJA); Q55338 (PYRB_SULAC); [ Recover all ] |
Triggered by |
HAMAP; MF_00001 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PYRB |
Protein name | RecName: Full=Aspartate carbamoyltransferase; EC=2.1.3.2; AltName: Full=Aspartate transcarbamylase; Short=ATCase; |
Gene name | Name=pyrB; |
Comments
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CATALYTIC ACTIVITY | Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L- aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228; EC=2.1.3.2; |
PATHWAY | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. |
case <OC:Archaea> | |
SUBUNIT | Heterooligomer of catalytic and regulatory chains. |
end case | |
SIMILARITY | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. |
Keywords
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Gene Ontology
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GO:0004070; Molecular function:aspartate carbamoyltransferase activity |
GO:0006221; Biological process:pyrimidine nucleotide biosynthetic process |
Cross-references
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Pfam | PF00185; OTCace; 1; |
NCBIfam | TIGR00670; asp_carb_tr; 1; |
PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
Features
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Additional information
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Size range | 291-475 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: MF_00002 (pyrI) |