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HAMAP rule MF_00001

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General rule information [?]

Accession MF_00001
Dates 1-JUN-2001 (Created)
14-MAY-2024 (Last updated, Version 38)
Name Asp_carb_tr
Scope(s) Bacteria
Archaea
Template(s) P0A786 (PYRB_ECOLI); P05654 (PYRB_BACSU); Q58976 (PYRB_METJA); Q55338 (PYRB_SULAC); [ Recover all ]
Triggered by HAMAP; MF_00001 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PYRB
Protein name RecName: Full=Aspartate carbamoyltransferase;
                 EC=2.1.3.2;
AltName: Full=Aspartate transcarbamylase;
                 Short=ATCase;
Gene name Name=pyrB;

Comments [?]

FUNCTIONCatalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
CATALYTIC ACTIVITY Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L- aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228; EC=2.1.3.2;
PATHWAYPyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
case <OC:Bacteria>
SUBUNITHeterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).
else case <OC:Archaea>
SUBUNITHeterooligomer of catalytic and regulatory chains.
end case
SIMILARITYBelongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

Keywords [?]


Gene Ontology [?]

GO:0004070; Molecular function:aspartate carbamoyltransferase activity
GO:0044205; Biological process:'de novo' UMP biosynthetic process

Cross-references [?]

Pfam PF00185; OTCace; 1;
NCBIfam TIGR00670; asp_carb_tr; 1;
PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;

Features [?]

From: PYRB_ECOLI (P0A786)
Key From To Description Tag Condition FTGroup
BINDING 55 55 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
R
BINDING 56 56 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
T
BINDING 85 85 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
K
BINDING 106 106 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
R
BINDING 135 135 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
H
BINDING 138 138 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
Q
BINDING 168 168 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
R
BINDING 230 230 /ligand="L-aspartate"
/ligand_id="ChEBI:CHEBI:29991"
R
BINDING 268 268 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
[GASL]
BINDING 269 269 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
P

Additional information [?]

Size range 291-475 amino acids
Related rules None
Fusion Nter: None Cter: MF_00002 (pyrI)



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