HAMAP rule MF_00007

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00007
Accession	MF_00007
Dates	28-FEB-2005 (Created) 21-MAR-2025 (Last updated, Version 22)
Name	DNA_primase_DnaG_arc
Scope(s)	Archaea
Template(s)	P95980; [ Recover all ]
Triggered by	HAMAP; MF_00007 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DNAG
Protein name	RecName: Full=DNA primase DnaG; EC=2.7.7.101;
Gene name	Name=dnaG;

Comments [?]

case <OC:Halobacteriales> or <OC:Methanococcales> or <OC:Methanomicrobiales>
FUNCTION	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
SUBUNIT	Forms a ternary complex with MCM helicase and DNA.
else
FUNCTION	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
SUBUNIT	Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
end case
CATALYTIC ACTIVITY	Reaction=ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.; EC=2.7.7.101;
SIMILARITY	Belongs to the archaeal DnaG primase family.

Keywords [?]

DNA replication
DNA-directed RNA polymerase
Nucleotidyltransferase
Primosome
Transcription
Transferase
case not <OC:Halobacteriales> and not <OC:Methanococcales> and not <OC:Methanomicrobiales>
Exosome
end case

Gene Ontology [?]

GO:0003899; Molecular function:DNA-directed RNA polymerase activity

GO:0006269; Biological process:DNA replication, synthesis of primer

Cross-references [?]

Pfam	PF01751; Toprim; 1;
PROSITE	PS50880; TOPRIM; 1;

Features [?]

Additional information [?]