HAMAP rule MF_00007

General rule information [?]

Accession	MF_00007
Dates	1-JUN-2001 (Created) 28-APR-2022 (Last updated, Version 25)

Name	DNA_primase_DnaG_arc

Scope

Archaea

Template

P95980 (DNAG_SACS2)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DNAG

Protein name

RecName:		Full=DNA primase DnaG;
		EC 2.7.7.101;

Gene name

dnaG

Comments [?]

case <OC:Halobacteriales> or <OC:Methanococcales> or <OC:Methanomicrobiales>

Function	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Subunit	Forms a ternary complex with MCM helicase and DNA.

else

Function	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
Subunit	Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.

end case

Catalytic activity	Reaction=ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.; EC=2.7.7.101;
Similarity	Belongs to the archaeal DnaG primase family.

Keywords [?]

case not <OC:Halobacteriales> and not <OC:Methanococcales> and not <OC:Methanomicrobiales>

end case

Gene Ontology [?]

GO:0003896; Molecular function: DNA primase activity.
GO:0006269; Biological process: DNA replication, synthesis of RNA primer.

Cross-references [?]

Pfam	PF01751; Toprim; 1;
PROSITE	PS50880; TOPRIM; 1; trigger=PRU00995;

Additional information [?]