HAMAP rule MF_00030

General rule information [?]

Accession	MF_00030
Dates	1-JUN-2001 (Created) 3-SEP-2024 (Last updated, Version 27)
Name	dGTPase_type1
Scope(s)	Bacteria
Template(s)	P15723 (DGTP_ECOLI); Q59827 (DGTP_SHIBO); [ Recover all ]
Triggered by	HAMAP; MF_00030 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DGTP
case <OC:Enterobacterales>
Protein name	RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase; Short=dGTP triphosphohydrolase; Short=dGTPase; EC=3.1.5.1;
else
Protein name	RecName: Full=Probable deoxyguanosinetriphosphate triphosphohydrolase; Short=dGTP triphosphohydrolase; Short=dGTPase; EC=3.1.5.1;
end case
Gene name	Name=dgt;

Comments [?]

FUNCTION	dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
CATALYTIC ACTIVITY	Reaction=dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+); Xref=Rhea:RHEA:15193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17172, ChEBI:CHEBI:18036, ChEBI:CHEBI:61429; EC=3.1.5.1;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Enterobacterales>
SUBUNIT	Homotetramer.
end case
SIMILARITY	Belongs to the dGTPase family. Type 1 subfamily.
case not <OC:Enterobacterales>
CAUTION	As this bacterium is not an Enterobacterale, this protein may not have a true dGTPase activity.
end case

Keywords [?]

Gene Ontology [?]

GO:0008832; Molecular function:dGTPase activity

GO:0000287; Molecular function:magnesium ion binding

Cross-references [?]

Pfam	PF01966; HD; 1;
PROSITE	PS51831; HD; 1;

Features [?]

Additional information [?]