HAMAP rule MF_00037

General rule information [?]

Accession	MF_00037
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 39)

Name

MurB

Scope

Bacteria

Templates

P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU): [Recover all]

Triggered by

HAMAP; MF_00037 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MURB

Protein name

RecName:		Full=UDP-N-acetylenolpyruvoylglucosamine reductase;
		EC 1.3.1.98;
AltName:		Full=UDP-N-acetylmuramate dehydrogenase;

Gene name

murB

Comments [?]

Function	Cell wall formation.
Catalytic activity	RHEA:12248: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC 1.3.1.98
Cofactor	FAD
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cytoplasm.
Similarity	Belongs to the MurB family.

Keywords [?]

Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
FAD
Flavoprotein
NADP
Oxidoreductase
Peptidoglycan synthesis

Gene Ontology [?]

GO:0008762; Molecular function: UDP-N-acetylmuramate dehydrogenase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS51387; FAD_PCMH; 1; trigger=PRU00718;
Pfam	PF01565; FAD_binding_4; 1;
	PF02873; MurB_C; 1;
NCBIfam	TIGR00179; MurB; 1;

Features [?]

From: MURB_ECOLI (P08373)

Key From To Description Tag Condition FTGroup

ACT_SITE 159 159 R

ACT_SITE 229 229 Proton donor [CS]

ACT_SITE 325 325 E

Additional information [?]

Size range	258-383 amino acids
Related rules	None
Fusion	None
Comments	Possible wrong start in NOSS1 and SYNY3. Divergent sequences in BIFLO and TREPA.

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