HAMAP rule MF_00037
General rule information
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| Accession | MF_00037 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39) |
| Name | MurB |
| Scope(s) |
Bacteria |
| Template(s) | P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MURB |
| Protein name | RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase; EC=1.3.1.98; AltName: Full=UDP-N-acetylmuramate dehydrogenase; |
| Gene name | Name=murB; |
Comments
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| FUNCTION | Cell wall formation. |
| CATALYTIC ACTIVITY | Reaction=NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine; Xref=Rhea:RHEA:12248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:68483, ChEBI:CHEBI:70757; EC=1.3.1.98; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the MurB family. |
Keywords
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| Cell cycle |
| Cell division |
| Cell shape |
| Cell wall biogenesis/degradation |
| Cytoplasm |
| FAD |
| Flavoprotein |
| NADP |
| Oxidoreductase |
| Peptidoglycan synthesis |
Gene Ontology
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| GO:0008762; Molecular function:UDP-N-acetylmuramate dehydrogenase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS51387; FAD_PCMH; 1; |
| Pfam | PF01565; FAD_binding_4; 1; |
| Pfam | PF02873; MurB_C; 1; |
| NCBIfam | TIGR00179; MurB; 1; |
Features
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| From: MURB_ECOLI (P08373) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 159 | 159 | R | |||||||||
| ACT_SITE | 229 | 229 | /note="Proton donor" | [CS] | ||||||||
| ACT_SITE | 325 | 325 | E | |||||||||
Additional information
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| Size range | 258-383 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in NOSS1 and SYNY3. Divergent sequences in BIFLO and TREPA. |