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HAMAP rule MF_00037

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General rule information [?]

Accession MF_00037
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name MurB
Templates P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase;
AltName: Full=UDP-N-acetylmuramate dehydrogenase;
Gene name

Comments [?]

Function Cell wall formation.
Catalytic activity RHEA:12248: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
Cofactor FAD
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the MurB family.

Keywords [?]

Gene Ontology [?]

GO:0008762; Molecular function: UDP-N-acetylmuramate dehydrogenase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51387; FAD_PCMH; 1; trigger=PRU00718;
Pfam PF01565; FAD_binding_4; 1;
PF02873; MurB_C; 1;
NCBIfam TIGR00179; MurB; 1;

Features [?]

From: MURB_ECOLI (P08373)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     159     159             R  
ACT_SITE     229     229       Proton donor     [CS]  
ACT_SITE     325     325             E  

Additional information [?]

Size range 258-383 amino acids
Related rules None
Fusion None
Comments Possible wrong start in NOSS1 and SYNY3. Divergent sequences in BIFLO and TREPA.