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HAMAP rule MF_00037

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General rule information [?]

Accession MF_00037
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name MurB
Scope(s) Bacteria
Template(s) P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU); [ Recover all ]
Triggered by HAMAP; MF_00037 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURB
Protein name RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase;
AltName: Full=UDP-N-acetylmuramate dehydrogenase;
Gene name Name=murB;

Comments [?]

FUNCTIONCell wall formation.
CATALYTIC ACTIVITY Reaction=NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine; Xref=Rhea:RHEA:12248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:68483, ChEBI:CHEBI:70757; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the MurB family.

Keywords [?]

Gene Ontology [?]

GO:0008762; Molecular function:UDP-N-acetylmuramate dehydrogenase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01565; FAD_binding_4; 1;
Pfam PF02873; MurB_C; 1;
NCBIfam TIGR00179; MurB; 1;

Features [?]

From: MURB_ECOLI (P08373)
Key From To Description Tag Condition FTGroup
ACT_SITE 159 159 R
ACT_SITE 229 229 /note="Proton donor" [CS]
ACT_SITE 325 325 E

Additional information [?]

Size range 258-383 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in NOSS1 and SYNY3. Divergent sequences in BIFLO and TREPA.

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