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Annotation rule MF_00054 |
Accession | MF_00054 |
Dates | 1-JUN-2001 (Created) 20-NOV-2019 (Last updated, Version 37) |
Name | EF_G_EF_2 |
Scope | Bacteria
Archaea |
Templates | P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SACS2): [Recover all] |
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Function | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. |
Pfam | PF00679; EFG_C; 1; |
PF00009; GTP_EFTU; 1; | |
PF03144; GTP_EFTU_D2; 1; | |
PRINTS | PR00315; ELONGATNFCT; 1; |
TIGRFAMs | TIGR00231; Small_GTP; 1; |
TIGR00484; EF-G; 1; | |
TIGR00490; AEF-2; 1; | |
PROSITE | PS00301; G_TR_1; 1; |
PS51722; G_TR_2; 1; |
From: EFG_ECOLI (P0A6M8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 17 | 24 | GTP | [AS]-H-[IV]-D-[AS]-G-K-T | ||||||||
NP_BIND | 88 | 92 | GTP | D-T-P-G-H | ||||||||
NP_BIND | 142 | 145 | GTP | N-K-x-D |
From: EF2_SACS2 (P30925) | ||||||||||||
NP_BIND | 27 | 34 | GTP | A-H-[IV]-[DH]-H-G-K-T | ||||||||
NP_BIND | 93 | 97 | GTP | D-T-P-G-H | ||||||||
NP_BIND | 147 | 150 | GTP | N-K-[IV]-D | ||||||||
MOD_RES | 603 | 603 | Diphthamide | H |
Size range | 669-715 amino acids |
Size range | 726-743 amino acids |
Related rules | MF_03063 (EFGC supersedes the current rule) |
Fusion | None |
Comments | EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met |