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HAMAP rule MF_00054

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General rule information [?]

Accession MF_00054
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 43)
Name EF_G_EF_2
Scope(s) Bacteria
Template(s) P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SACS2); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00054_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00054_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria>
Identifier EFG
Protein name RecName: Full=Elongation factor G;
end case
case <OC:Archaea>
Identifier EF2
Protein name RecName: Full=Elongation factor 2;
end case
Gene name Name=fusA;

Comments [?]

FUNCTIONCatalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
SIMILARITYBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function:GTP binding
GO:0003746; Molecular function:translation elongation factor activity
GO:0006414; Biological process:translational elongation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00679; EFG_C; 1;
Pfam PF00009; GTP_EFTU; 1;
Pfam PF03144; GTP_EFTU_D2; 1;
NCBIfam TIGR00231; Small_GTP; 1;
NCBIfam TIGR00484; EF-G; 1;
NCBIfam TIGR00490; AEF-2; 1;
PROSITE PS00301; G_TR_1; 1;
PROSITE PS51722; G_TR_2; 1;

Features [?]

From: EFG_ECOLI (P0A6M8)
Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
BINDING 17 24 /ligand="GTP"
BINDING 88 92 /ligand="GTP"
BINDING 142 145 /ligand="GTP"
end case
From: EF2_SACS2 (P30925)
Key From To Description Tag Condition FTGroup
case <OC:Archaea>
BINDING 27 34 /ligand="GTP"
BINDING 93 97 /ligand="GTP"
BINDING 147 150 /ligand="GTP"
MOD_RES 603 603 /note="Diphthamide" H
end case

Additional information [?]

Size range 726-743 amino acids
Related rules MF_03063
Fusion Nter: None Cter: None
Comments EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met

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