HAMAP rule MF_00054
General rule information
[?]
Accession | MF_00054 |
Dates | 1-JUN-2001 (Created) 23-JAN-2023 (Last updated, Version 41) |
Name | EF_G_EF_2 |
Scope | Bacteria
Archaea |
Templates | P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SACS2): [Recover all] |
case <OC:Bacteria>
Triggered by |
end case
case <OC:Archaea>
Triggered by |
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Bacteria>
Identifier |
|
Protein name |
|
end case
case <OC:Archaea>
Identifier |
|
Protein name |
|
end case
Gene name |
|
Comments
[?]
Function | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
Pfam | PF00679; EFG_C; 1; |
PF00009; GTP_EFTU; 1; | |
PF03144; GTP_EFTU_D2; 1; | |
PRINTS | PR00315; ELONGATNFCT; 1; |
TIGRFAMs | TIGR00231; Small_GTP; 1; |
TIGR00484; EF-G; 1; | |
TIGR00490; AEF-2; 1; | |
PROSITE | PS00301; G_TR_1; 1; |
PS51722; G_TR_2; 1; |
Features
[?]
case <OC:Bacteria>
From: EFG_ECOLI (P0A6M8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 17 | 24 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | [AS]-H-[IV]-D-[AS]-G-K-T | ||||||||
BINDING | 88 | 92 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-T-P-G-H | ||||||||
BINDING | 142 | 145 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-x-D |
end case
case <OC:Archaea>
From: EF2_SACS2 (P30925) | ||||||||||||
BINDING | 27 | 34 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | A-H-[IV]-[DH]-H-G-K-T | ||||||||
BINDING | 93 | 97 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-T-P-G-H | ||||||||
BINDING | 147 | 150 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-[IV]-D | ||||||||
MOD_RES | 603 | 603 | Diphthamide | H |
end case
Additional information
[?]
case <OC:Bacteria>
Size range | 669-715 amino acids |
end case
case <OC:Archaea>
Size range | 726-743 amino acids |
end case
Related rules | MF_03063 (EFGC supersedes the current rule) |
Fusion | None |
Comments | EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met |