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HAMAP rule MF_00054

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General rule information [?]

Accession MF_00054
Dates 1-JUN-2001 (Created)
23-JAN-2023 (Last updated, Version 41)
Name EF_G_EF_2
Templates P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SACS2): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria>
Protein name
RecName: Full=Elongation factor G;
end case
case <OC:Archaea>
Protein name
RecName: Full=Elongation factor 2;
end case
Gene name

Comments [?]

Function Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular location Cytoplasm.
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00679; EFG_C; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
TIGRFAMs TIGR00231; Small_GTP; 1;
TIGR00484; EF-G; 1;
TIGR00490; AEF-2; 1;
PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1;

Features [?]

case <OC:Bacteria>
From: EFG_ECOLI (P0A6M8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     17     24       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [AS]-H-[IV]-D-[AS]-G-K-T  
BINDING     88     92       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-T-P-G-H  
BINDING     142     145       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-x-D  
end case
case <OC:Archaea>
From: EF2_SACS2 (P30925)
BINDING     27     34       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     A-H-[IV]-[DH]-H-G-K-T  
BINDING     93     97       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-T-P-G-H  
BINDING     147     150       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-[IV]-D  
MOD_RES     603     603       Diphthamide     H  
end case

Additional information [?]

case <OC:Bacteria>
Size range 669-715 amino acids
end case
case <OC:Archaea>
Size range 726-743 amino acids
end case
Related rules MF_03063 (EFGC supersedes the current rule)
Fusion None
Comments EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met