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HAMAP rule MF_00060

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General rule information [?]

Accession MF_00060
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name SurE
Templates P96112 (SURE_THEMA); P0A840 (SURE_ECOLI); Q8ZU79 (SURE1_PYRAE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Protein name
RecName: Full=5'/3'-nucleotidase SurE;
AltName: Full=Exopolyphosphatase;
AltName: Full=Nucleoside monophosphate phosphohydrolase;
end case
case not <OC:Enterobacterales>
Protein name
RecName: Full=5'-nucleotidase SurE;
AltName: Full=Nucleoside 5'-monophosphate phosphohydrolase;
end case
Gene name

Comments [?]

case <OC:Enterobacterales>
Function Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
Catalytic activity RHEA:12484: a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
RHEA:10144: a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate
RHEA:21528: [phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate
end case
case not <OC:Enterobacterales>
Function Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Catalytic activity RHEA:12484: a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
end case
Cofactor a divalent metal cation
Note: Binds 1 divalent metal cation per subunit.
Subcellular location Cytoplasm.
Similarity Belongs to the SurE nucleotidase family.

Keywords [?]

Gene Ontology [?]

GO:0008253; Molecular function: 5'-nucleotidase activity.
case <OC:Enterobacterales>
GO:0004309; Molecular function: exopolyphosphatase activity.
GO:0008254; Molecular function: 3'-nucleotidase activity.
end case
GO:0046872; Molecular function: metal ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01975; SurE; 1;
NCBIfam TIGR00087; SurE; 1;

Features [?]

From: SURE_THEMA (P96112)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     8     8       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
BINDING     9     9       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D  
BINDING     39     39       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     S  
BINDING     95     95       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     N  

Additional information [?]

Size range 244-283 amino acids
Related rules None
Fusion None
Comments In some organisms, surE was originally annotated as an acid phosphatase (EC Weird C-terminal sequence in TREPA; no obvious frameshift; not shown in alignment and not used in size range. There are divergent second copies of surE in NOSS1 (alr3139) and SYNY3 (sll1459).