HAMAP rule MF_00064
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00064 |
| Accession | MF_00064 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 21) |
| Name | Sulf_adenylyltr_sub2 |
| Scope(s) |
Bacteria |
| Template(s) | P21156; [ Recover all ] |
| Triggered by |
HAMAP; MF_00064 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CYSD |
| Protein name | RecName: Full=Sulfate adenylyltransferase subunit 2; EC=2.7.7.4; AltName: Full=ATP-sulfurylase small subunit; AltName: Full=Sulfate adenylate transferase; Short=SAT; |
| Gene name | Name=cysD; |
Comments
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| FUNCTION | With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric- sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD. |
| CATALYTIC ACTIVITY | Reaction=sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate; Xref=Rhea:RHEA:18133, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58243; EC=2.7.7.4; |
| PATHWAY | Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. |
| SUBUNIT | Heterodimer composed of CysD, the smaller subunit, and CysN. |
| SIMILARITY | Belongs to the PAPS reductase family. CysD subfamily. |
Keywords
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Gene Ontology
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| GO:0004781; Molecular function:sulfate adenylyltransferase (ATP) activity |
| GO:0000103; Biological process:sulfate assimilation |
| GO:0070814; Biological process:hydrogen sulfide biosynthetic process |
Cross-references
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| Pfam | PF01507; PAPS_reduct; 1; |
Features
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Additional information
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| Size range | 296-328 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | If in a nodulating bacteria, has to be done manually because of the presence of both cysD and nodP |