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HAMAP rule MF_00064

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General rule information [?]

Accession MF_00064
Dates 1-JUN-2001 (Created)
26-OCT-2021 (Last updated, Version 28)
Name Sulf_adenylyltr_sub2
Scope(s) Bacteria
Template(s) P21156 (CYSD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00064 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CYSD
Protein name RecName: Full=Sulfate adenylyltransferase subunit 2;
AltName: Full=ATP-sulfurylase small subunit;
AltName: Full=Sulfate adenylate transferase;
Gene name Name=cysD;

Comments [?]

FUNCTIONWith CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric- sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
CATALYTIC ACTIVITY Reaction=ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate; Xref=Rhea:RHEA:18133, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58243; EC=;
PATHWAYSulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
SUBUNITHeterodimer composed of CysD, the smaller subunit, and CysN.
SIMILARITYBelongs to the PAPS reductase family. CysD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004781; Molecular function:sulfate adenylyltransferase (ATP) activity
GO:0000103; Biological process:sulfate assimilation

Cross-references [?]

Pfam PF01507; PAPS_reduct; 1;

Features [?]

Additional information [?]

Size range 296-328 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments If in a nodulating bacteria, has to be done manually because of the presence of both cysD and nodP

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