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HAMAP rule MF_00067

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General rule information [?]

Accession MF_00067
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name GmhA
Scope(s) Bacteria
Template(s) P63224 (GMHA_ECOLI); Q93UJ2 (GMHA_BURPS); Q9HVZ0 (GMHA_PSEAE); Q9AGY7 (GMHA_ANETH); [ Recover all ]
Triggered by HAMAP; MF_00067 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GMHA
case <OC:Bacteria>
Protein name RecName: Full=Phosphoheptose isomerase;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable phosphoheptose isomerase;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
Gene name Name=gmhA;

Comments [?]

FUNCTIONCatalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
CATALYTIC ACTIVITY Reaction=2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno- heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate; Xref=Rhea:RHEA:27489, ChEBI:CHEBI:57483, ChEBI:CHEBI:60203, ChEBI:CHEBI:60204; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
PATHWAYCarbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7- phosphate: step 1/1.
case <OC:Pseudomonadota>
end case
MISCELLANEOUSThe reaction produces a racemic mixture of D-glycero- alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7- phosphate.
SIMILARITYBelongs to the SIS family. GmhA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding
GO:0008968; Molecular function:D-sedoheptulose 7-phosphate isomerase activity
GO:0005975; Biological process:carbohydrate metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS51464; SIS; 1;
Pfam PF01380; SIS; 1;
NCBIfam TIGR00441; GmhA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 55 57 /ligand="substrate" N-x-G
BINDING 97 98 /ligand="substrate" N-D
BINDING 123 125 /ligand="substrate" [ST]-T-S
BINDING 64 64 /ligand="Zn(2+)"
BINDING 68 68 /ligand="Zn(2+)"
BINDING 175 175 /ligand="Zn(2+)"
BINDING 183 183 /ligand="Zn(2+)"
BINDING 68 68 /ligand="substrate" [EQN]
BINDING 128 128 /ligand="substrate" S
BINDING 175 175 /ligand="substrate" [QH]

Additional information [?]

Size range 182-231 amino acids
Related rules None
Fusion Nter: None Cter: None

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