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Annotation rule MF_00067
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General rule information [?]

Accession MF_00067
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 27)
Name GmhA
Scope
Bacteria
Archaea
Templates P63224 (GMHA_ECOLI); Q93UJ2 (GMHA_BURPS); Q9HVZ0 (GMHA_PSEAE); Q9AGY7 (GMHA_ANETH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GMHA
case <OC:Bacteria>
Protein name
RecName: Full=Phosphoheptose isomerase;
EC 5.3.1.28;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable phosphoheptose isomerase;
EC 5.3.1.28;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
Gene name
gmhA

Comments [?]

Function Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Catalytic activity RHEA:27489: 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
EC 5.3.1.28
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
case <OC:Proteobacteria>
Subunit Homotetramer.
end case
Subcellular location Cytoplasm.
Miscellaneous The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Similarity Belongs to the SIS family. GmhA subfamily.

Keywords [?]

Cytoplasm
Carbohydrate metabolism
Isomerase
Metal-binding
Zinc

Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0008968; Molecular function: D-sedoheptulose 7-phosphate isomerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51464; SIS; 1; trigger=PRU00797;
Pfam PF01380; SIS; 1;
TIGRFAMs TIGR00441; GmhA; 1;

Features [?]

From: GMHA_BURPS (Q93UJ2)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     55     57       Substrate binding     N-x-G  
REGION     97     98       Substrate binding     N-D  
REGION     123     125       Substrate binding     [ST]-T-S  
METAL     64     64       Zinc     H  
METAL     68     68       Zinc     [EQN]  
METAL     175     175       Zinc     [QH]  
METAL     183     183       Zinc     H  
BINDING     68     68       Substrate     [EQN]  
BINDING     128     128       Substrate     S  
BINDING     175     175       Substrate     [QH]  

Additional information [?]

Size range 182-231 amino acids
Related rules None
Fusion None


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