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HAMAP rule MF_00069

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General rule information [?]

Accession MF_00069
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 42)
Name Hydroxylam_reduct
Templates P31101 (HCP_DESVH); Q01770 (HCP_DESDA); P75825 (HCP_ECOLI); Q6WRT6 (HCP_RHOCA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Hydroxylamine reductase;
AltName: Full=Hybrid-cluster protein;
AltName: Full=Prismane protein;
Gene name

Comments [?]

Function Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
Catalytic activity RHEA:22052: A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine
case <OC:Gammaproteobacteria> and <FTGroup:1>
Cofactor [2Fe-2S] cluster
Note: Binds 1 [2Fe-2S] cluster.
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster.
end case
case <FTGroup:3>
Cofactor hybrid [4Fe-2O-2S] cluster
Note: Binds 1 hybrid [4Fe-2O-2S] cluster.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the HCP family.

Keywords [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
end case
case <OC:Gammaproteobacteria> and <FTGroup:1>
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0050418; Molecular function: hydroxylamine reductase activity.
GO:0051536; Molecular function: iron-sulfur cluster binding.

Cross-references [?]

Pfam PF03063; Prismane; 1;
NCBIfam TIGR01703; hybrid_clust; 1;

Features [?]

case <OC:Gammaproteobacteria>
From: HCP_ECOLI (P75825)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     3     3       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     6     6       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     18     18       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     25     25       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
end case
case not <OC:Gammaproteobacteria>
From: HCP_DESVH (P31101)
BINDING     3     3       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   2
BINDING     6     6       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   2
BINDING     15     15       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   2
BINDING     21     21       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   2
end case
BINDING     244     244       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     H   3
BINDING     268     268       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     E   3
BINDING     312     312       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     C   3
BINDING     406     406       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" /note="via persulfide group     C   3
BINDING     434     434       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     C   3
BINDING     459     459       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     C   3
BINDING     494     494       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     E   3
BINDING     496     496       /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519     K   3
MOD_RES     406     406       Cysteine persulfide     C  

Additional information [?]

Size range 427-570 amino acids
Related rules None
Fusion None
Comments Possible wrong start in THEMA and ACIFR. Deleted domain in THEMA/METTH.