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HAMAP rule MF_00082

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General rule information [?]

Accession MF_00082
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 60)
Name ArgB
Scope
Bacteria
Archaea
Plastid
Templates P0A6C8 (ARGB_ECOLI); Q9HTN2 (ARGB_PSEAE); Q9X2A4 (ARGB_THEMA); Q72HA9 (ARGB_THET2); P9WQ01 (ARGB_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ARGB
Protein name
RecName: Full=Acetylglutamate kinase;
EC 2.7.2.8;
AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase;
AltName: Full=NAG kinase;
Short=NAGK;
Gene name
argB

Comments [?]

Function Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Catalytic activity RHEA:14629: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate
EC 2.7.2.8
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
case <OC:Bacteria> or <OC:Archaea>
Subcellular location Cytoplasm.
else case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the acetylglutamate kinase family. ArgB subfamily.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
ATP-binding
case <OC:Bacteria> or <OC:Archaea>
Cytoplasm
end case
Kinase
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0003991; Molecular function: acetylglutamate kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
case <OC:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
PRINTS PR00474; GLU5KINASE; 1;
NCBIfam TIGR00761; argB; 1;
PIRSF PIRSF000728; NAGK; 1;

Features [?]

case <OC:Enterobacterales>
From: ARGB_ECOLI (P0A6C8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     181     186       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     D-[VI]-S-[GS]-I-L  
BINDING (Optional)     209     211       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     I-I-T  
end case
BINDING (Optional)     44     45       /ligand="substrate     [GA]-[GSA]  
BINDING (Optional)     66     66       /ligand="substrate     R  
BINDING (Optional)     158     158       /ligand="substrate     N  
SITE     8     8       Transition state stabilizer     K  
SITE     217     217       Transition state stabilizer     K  

Additional information [?]

Size range 220-390 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments Signature does not match Xanthomonadaceae, which have a longer C-terminus.


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