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HAMAP rule MF_00082

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General rule information [?]

Accession MF_00082
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 60)
Name ArgB
Scope(s) Bacteria
Archaea
Plastid
Template(s) P0A6C8 (ARGB_ECOLI); Q9HTN2 (ARGB_PSEAE); Q9X2A4 (ARGB_THEMA); Q72HA9 (ARGB_THET2); P9WQ01 (ARGB_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_00082 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARGB
Protein name RecName: Full=Acetylglutamate kinase;
                 EC=2.7.2.8;
AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase;
AltName: Full=NAG kinase;
                 Short=NAGK;
Gene name Name=argB;

Comments [?]

FUNCTIONCatalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate.
CATALYTIC ACTIVITY Reaction=ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5- phosphate; Xref=Rhea:RHEA:14629, ChEBI:CHEBI:30616, ChEBI:CHEBI:44337, ChEBI:CHEBI:57936, ChEBI:CHEBI:456216; EC=2.7.2.8;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 2/4.
case <OC:Enterobacterales>
SUBUNITHomodimer.
end case
case <OC:Bacteria> or <OC:Archaea>
SUBCELLULAR LOCATIONCytoplasm.
else case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the acetylglutamate kinase family. ArgB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003991; Molecular function:acetylglutamate kinase activity
GO:0005524; Molecular function:ATP binding
GO:0042450; Biological process:arginine biosynthetic process via ornithine
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case
case <OCellular component:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
PRINTS PR00474; GLU5KINASE; 1;
NCBIfam TIGR00761; argB; 1;
PIRSF PIRSF000728; NAGK; 1;

Features [?]

From: ARGB_ECOLI (P0A6C8)
Key From To Description Tag Condition FTGroup
case <OC:Enterobacterales>
BINDING 181 186 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D-[VI]-S-[GS]-I-L
BINDING 209 211 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
I-I-T
end case
BINDING 44 45 /ligand="substrate" [GA]-[GSA]
BINDING 66 66 /ligand="substrate" R
BINDING 158 158 /ligand="substrate" N
SITE 8 8 /note="Transition state stabilizer" K
SITE 217 217 /note="Transition state stabilizer" K

Additional information [?]

Size range 220-390 amino acids
Related rules None
Fusion Nter: None Cter: <Unknown>
Comments Signature does not match Xanthomonadaceae, which have a longer C-terminus.



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