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Annotation rule MF_00098 |
General rule information
[?]
Accession |
MF_00098 |
Dates |
29-OCT-2002 (Created) 20-NOV-2019 (Last updated, Version 39) |
Name |
Met_tRNA_synth_type1 |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Methionine--tRNA ligase;
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EC 6.1.1.10;
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AltName:
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Full=Methionyl-tRNA synthetase;
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Short=MetRS;
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Function |
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. |
Catalytic activity |
RHEA:13481: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
EC 6.1.1.10
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case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
case <Feature:PS50886>
end case
case not <Feature:PS50886> and <OC:Bacteria>
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. |
case <Feature:PS50886>
end case
case <FTGroup:1>
end case
GO:0005524; Molecular function: ATP binding.
GO:0004825; Molecular function: methionine-tRNA ligase activity.
GO:0006431; Biological process: methionyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
From: SYM_ECOLI (P00959) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOTIF
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15
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25
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'HIGH' region
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[PYA]-[YT]-x(5)-H-[LIVFA]-G-[HNST]
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MOTIF
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333
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337
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'KMSKS' region
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[KTQ]-[LIMF]-[SG]-[KTS]-[ST]
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METAL
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146
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146
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Zinc
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C
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1
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METAL
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149
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149
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Zinc
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C
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1
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METAL
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159
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159
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Zinc
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C
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1
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METAL
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162
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162
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Zinc
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C
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1
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BINDING
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336
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336
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ATP
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[KST]
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Additional information
[?]
Size range |
536-734 amino acids |
Related rules |
MF_01228 (SYM) |
Fusion |
None |
Comments |
It is possible that several species such as ARCFU, METAC, METMA, METKA, METTH, METJA and TREPA bind a second zinc ion, as their sequences contain a second zinc finger motif corresponding to that of metG subfamily 2 |