||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
||Reaction=Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.; EC=188.8.131.52;
||RHEA:66592: (DNA)-(deoxyribonucleoside 5'-phosphate)-(deoxyribose 5'-phosphate)-(deoxyribonucleoside 5'-phosphate) = (DNA)-3'-(deoxyribonucleoside 5'-phosphate)-(2,3-dehydro-2,3-deoxyribose 5'-phosphate) + H(+) + phospho-5'-(DNA)
Note: Binds 1 zinc ion per subunit.
||Belongs to the FPG family.