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HAMAP rule MF_00105

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General rule information [?]

Accession MF_00105
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 24)
Name GreA_GreB
Scope(s) Bacteria
Template(s) P0A6W5 (GREA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GREA
Protein name RecName: Full=Transcription elongation factor GreA;
AltName: Full=Transcript cleavage factor GreA;
Gene name Name=greA;

Comments [?]

FUNCTIONNecessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
SIMILARITYBelongs to the GreA/GreB family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0032784; Biological process:regulation of DNA-templated transcription elongation

Cross-references [?]

PROSITE PS00829; GREAB_1; 1;
PROSITE PS00830; GREAB_2; 1;
Pfam PF01272; GreA_GreB; 1;
Pfam PF03449; GreA_GreB_N; 1;
NCBIfam TIGR01462; greA; 1;
PIRSF PIRSF006092; GreA_GreB; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

Additional information [?]

Size range 140-266 amino acids
Related rules MF_00930
Fusion Nter: <GRAD1>; <GRAD2> Cter: None
Comments In CHLPN and CHLTR the protein is fused to a N-terminal domain, GRAD1. In BORBU the protein is fused to both the GRAD1 domain and another N-terminal domain, GRAD2. Duplicate copy is called greB (annotated by MF_00930).

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