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Annotation rule MF_00105
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General rule information [?]

Accession MF_00105
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 22)
Name GreA_GreB
Scope
Bacteria
Template P0A6W5 (GREA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GREA
Protein name
RecName: Full=Transcription elongation factor GreA;
AltName: Full=Transcript cleavage factor GreA;
Gene name
greA

Comments [?]

Function Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Similarity Belongs to the GreA/GreB family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0032784; Biological process: regulation of DNA-templated transcription, elongation.

Cross-references [?]

PROSITE PS00829; GREAB_1; 1;
PS00830; GREAB_2; 1;
Pfam PF01272; GreA_GreB; 1;
PF03449; GreA_GreB_N; 1;
TIGRFAMs TIGR01462; greA; 1;
PIRSF PIRSF006092; GreA_GreB; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Additional information [?]

Size range 140-266 amino acids
Related rules MF_00930 (GREB supersedes the current rule)
Fusion Nter: <GRAD1>, <GRAD2>; Cter: None
Comments In CHLPN and CHLTR the protein is fused to a N-terminal domain, GRAD1. In BORBU the protein is fused to both the GRAD1 domain and another N-terminal domain, GRAD2. Duplicate copy is called greB (annotated by MF_00930).