HAMAP rule MF_00105
General rule information
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| Accession | MF_00105 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | GreA_GreB |
| Scope(s) |
Bacteria |
| Template(s) | P0A6W5 (GREA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00105 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GREA |
| Protein name | RecName: Full=Transcription elongation factor GreA; AltName: Full=Transcript cleavage factor GreA; |
| Gene name | Name=greA; |
Comments
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| FUNCTION | Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. |
| SIMILARITY | Belongs to the GreA/GreB family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0032784; Biological process:regulation of DNA-templated transcription elongation |
Cross-references
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| PROSITE | PS00829; GREAB_1; 1; |
| PROSITE | PS00830; GREAB_2; 1; |
| Pfam | PF01272; GreA_GreB; 1; |
| Pfam | PF03449; GreA_GreB_N; 1; |
| NCBIfam | TIGR01462; greA; 1; |
| PIRSF | PIRSF006092; GreA_GreB; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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Additional information
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| Size range | 140-266 amino acids |
| Related rules |
MF_00930 |
| Fusion | Nter: <GRAD1>; <GRAD2> Cter: None |
| Comments | In CHLPN and CHLTR the protein is fused to a N-terminal domain, GRAD1. In BORBU the protein is fused to both the GRAD1 domain and another N-terminal domain, GRAD2. Duplicate copy is called greB (annotated by MF_00930). |