HAMAP rule MF_00109

General rule information [?]

Accession	MF_00109
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 44)

Name	Shikimate_kinase

Scope

Bacteria

Templates

P0A6D7 (AROK_ECOLI); P9WPY3 (AROK_MYCTU): [Recover all]

Triggered by

HAMAP; MF_00109 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

AROK

case not <OC:Enterobacterales>

Protein name

RecName:		Full=Shikimate kinase;
		Short=SK;
		EC 2.7.1.71;

else case <OC:Enterobacterales>

Protein name

RecName:		Full=Shikimate kinase 1;
		Short=SK 1;
		EC 2.7.1.71;

end case

Gene name

aroK

Comments [?]

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity	RHEA:13121: ATP + shikimate = 3-phosphoshikimate + ADP + H(+) EC 2.7.1.71
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the shikimate kinase family.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Aromatic amino acid biosynthesis
ATP-binding
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0004765; Molecular function: shikimate kinase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01202; SKI; 1;
PRINTS	PR01100; SHIKIMTKNASE; 1;
PROSITE	PS01128; SHIKIMATE_KINASE; 1;

Features [?]

From: AROK_MYCTU (P9WPY3)

Key From To Description Tag Condition FTGroup

BINDING 12 17 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING 16 16 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [ST]

BINDING 34 34 /ligand="substrate D

BINDING 58 58 /ligand="substrate R

BINDING 80 80 /ligand="substrate G

BINDING 117 117 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [RK]

BINDING 136 136 /ligand="substrate R

BINDING (Optional) 153 153 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [RQ]

Additional information [?]

Size range	161-214 amino acids
Related rules	MF_01269 (AROL supersedes the current rule); MF_03143 (ARO1 supersedes the current rule)
Fusion	Nter: None; Cter: MF_00110 (aroB)
Comments	Archaeal aroK belong to a separate family (MF_00370). Enterobacterales (except WIGBR, BLOBP, BLOFL, BUCAI, BUCAP and BUCBP) possess a second shikimate kinase (aroL, MF_01269). Mg(2+) is six-coordinated in shikimate kinase 1 (aroK, MF_00109) with direct interaction with two protein side-chains, whereas it is four-coordinated in shikimate kinase 2 (aroL, MF_01269) with direct interaction with only one protein side-chain. Strange longer C-terminus in FRACC; sequence not included in size range.

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