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HAMAP rule MF_00114
General rule information
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| Accession | MF_00114 |
| Dates | 1-JUN-2001 (Created)
24-JAN-2024 (Last updated, Version 39) |
| Name | DeoC_type1 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9Y948 (DEOC_AERPE); P39121 (DEOC_BACSU); Q9X1P5 (DEOC_THEMA); Q5SJ28 (DEOC_THET8); Q8ZXK7 (DEOC_PYRAE); C0ZUQ6 (DEOC_RHOE4); [ Recover all ] |
| Triggered by |
HAMAP; MF_00114 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DEOC |
| Protein name | RecName: Full=Deoxyribose-phosphate aldolase; Short=DERA; EC=4.1.2.4; AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase; AltName: Full=Phosphodeoxyriboaldolase; Short=Deoxyriboaldolase; |
| Gene name | Name=deoC; |
Comments
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| FUNCTION | Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. |
| CATALYTIC ACTIVITY | Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343, ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4; |
| PATHWAY | Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 2/2. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0004139; Molecular function:deoxyribose-phosphate aldolase activity |
| GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: DEOC_BACSU (P39121) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 89 | 89 | /note="Proton donor/acceptor" | [DE] | ||||||||
| ACT_SITE | 152 | 152 | /note="Schiff-base intermediate with acetaldehyde" | K | ||||||||
| ACT_SITE | 181 | 181 | /note="Proton donor/acceptor" | K | ||||||||
Additional information
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| Size range | 200-325 amino acids |
| Related rules |
MF_00592 |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in AERPE and THEMA |