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Annotation rule MF_00117
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General rule information [?]

Accession MF_00117
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 20)
Name HslO
Scope
Bacteria
Template P0A6Y5 (HSLO_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HSLO
Protein name
RecName: Full=33 kDa chaperonin;
AltName: Full=Heat shock protein 33 homolog;
Short=HSP33;
Gene name
hslO

Comments [?]

Function Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
Subcellular location Cytoplasm.
Ptm Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.
Similarity Belongs to the HSP33 family.

Keywords [?]

Cytoplasm
Chaperone
Disulfide bond
Redox-active center
Zinc

Gene Ontology [?]

GO:0051082; Molecular function: unfolded protein binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01430; HSP33; 1;

Features [?]

From: HSLO_ECOLI (P0A6Y5)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     230     232       Redox-active     C-x-C  
DISULFID     263     266       Redox-active     C-x(2)-C  

Additional information [?]

Size range 281-341 amino acids
Related rules None
Fusion None
Comments Possible wrong start in AQUAE and DEIRA


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