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HAMAP rule MF_00118

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General rule information [?]

Accession MF_00118
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 46)
Name EF_Tu
Scope
Bacteria
Archaea
Plastid
Templates P35021 (EF1A_SACS2); P0CE47 (EFTU1_ECOLI); Q01698 (EFTU_THEAQ); P60338 (EFTU1_THETH); Q57770 (EF1A_METJA): [Recover all]
case <OC:Bacteria> or <OG:Chloroplast>
Triggered by
end case

case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacteria>
Identifier
EFTU
Protein name
RecName: Full=Elongation factor Tu;
Short=EF-Tu;
Gene name
tuf
else case <OC:Archaea>
Identifier
EF1A
Protein name
RecName: Full=Elongation factor 1-alpha;
Short=EF-1-alpha;
AltName: Full=Elongation factor Tu;
Short=EF-Tu;
Gene name
tuf
else case <OG:Chloroplast>
Identifier
EFTU
Protein name
RecName: Full=Elongation factor Tu, chloroplastic;
Short=EF-Tu;
Gene name
tufA
end case

Comments [?]

Function This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
case <OC:Bacteria>
Subunit Monomer.
Subcellular location Cytoplasm.
end case
case <OC:Archaea>
Subcellular location Cytoplasm.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

Keywords [?]

case not <OG:Chloroplast>
Cytoplasm
end case
Elongation factor
Protein biosynthesis
GTP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
case <OC:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component: cytoplasm.
end case
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00009; GTP_EFTU; 1;
PRINTS PR00315; ELONGATNFCT; 1;
NCBIfam TIGR00483; EF-1_alpha; 1;
TIGR00485; EF-Tu; 1;
PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1;

Features [?]

case <OC:Bacteria> or <OG:Chloroplast>
From: EFTU1_ECOLI (P0CE47)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     19     26       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-[HQ]-[IV]-[DY]-H-G-K-[ST]  
BINDING     81     85       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-x-P-G-H  
BINDING     136     139       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-x-D  
end case
case <OC:Archaea>
From: EF1A_METJA (Q57770)
BINDING     14     21       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-H-[IV]-D-[NHA]-G-K-S  
BINDING     91     95       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-x-P-G-H  
BINDING     149     152       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-M-D  
end case

Additional information [?]

Size range 350-550 amino acids
Related rules None
Fusion None
Comments Duplicated in some but not necessarily all Acidobacteriota, Pseudomonadota, Alkaliohilus, Clostrium, Chloroflexota, Deinococcus, Magnetococcus, Sphingobacter, Streptomyces, Syntrophobacter. Short versions in EHRRW, VIBVU, and a divergent copy in CHAGL are atypical.


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