HAMAP rule MF_00118
General rule information
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Accession | MF_00118 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 46) |
Name | EF_Tu |
Scope | Bacteria
Archaea
Plastid |
Templates | P35021 (EF1A_SACS2); P0CE47 (EFTU1_ECOLI); Q01698 (EFTU_THEAQ); P60338 (EFTU1_THETH); Q57770 (EF1A_METJA): [Recover all] |
case <OC:Bacteria> or <OG:Chloroplast>
Triggered by |
end case
case <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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case <OC:Bacteria>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Archaea>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OG:Chloroplast>
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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Function | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. |
case <OC:Bacteria>
Subunit | Monomer. |
Subcellular location | Cytoplasm. |
end case
case <OC:Archaea>
Subcellular location | Cytoplasm. |
end case
case <OG:Chloroplast>
Subcellular location | Plastid, chloroplast. |
end case
Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. |
Keywords
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case not <OG:Chloroplast>
end case
Gene Ontology
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GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0003746; Molecular function: translation elongation factor activity.
case <OC:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component: cytoplasm.
end case
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
Cross-references
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Pfam | PF00009; GTP_EFTU; 1; |
PRINTS | PR00315; ELONGATNFCT; 1; |
NCBIfam | TIGR00483; EF-1_alpha; 1; |
TIGR00485; EF-Tu; 1; | |
PROSITE | PS00301; G_TR_1; 1; |
PS51722; G_TR_2; 1; |
Features
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case <OC:Bacteria> or <OG:Chloroplast>
From: EFTU1_ECOLI (P0CE47) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 19 | 26 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | G-[HQ]-[IV]-[DY]-H-G-K-[ST] | ||||||||
BINDING | 81 | 85 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-x-P-G-H | ||||||||
BINDING | 136 | 139 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-x-D |
end case
case <OC:Archaea>
From: EF1A_METJA (Q57770) | ||||||||||||
BINDING | 14 | 21 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | G-H-[IV]-D-[NHA]-G-K-S | ||||||||
BINDING | 91 | 95 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-x-P-G-H | ||||||||
BINDING | 149 | 152 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-M-D |
end case
Additional information
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Size range | 350-550 amino acids |
Related rules | None |
Fusion | None |
Comments | Duplicated in some but not necessarily all Acidobacteriota, Pseudomonadota, Alkaliohilus, Clostrium, Chloroflexota, Deinococcus, Magnetococcus, Sphingobacter, Streptomyces, Syntrophobacter. Short versions in EHRRW, VIBVU, and a divergent copy in CHAGL are atypical. |