HAMAP rule MF_00118
General rule information
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| Accession | MF_00118 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 46) |
| Name | EF_Tu |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P35021 (EF1A_SACS2); P0CE47 (EFTU1_ECOLI); Q01698 (EFTU_THEAQ); P60338 (EFTU1_THETH); Q57770 (EF1A_METJA); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_00118_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_00118_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacteria> | |
| Identifier | EFTU |
| Protein name | RecName: Full=Elongation factor Tu; Short=EF-Tu; |
| Gene name | Name=tuf; |
| else case <OC:Archaea> | |
| Identifier | EF1A |
| Protein name | RecName: Full=Elongation factor 1-alpha; Short=EF-1-alpha; AltName: Full=Elongation factor Tu; Short=EF-Tu; |
| Gene name | Name=tuf; |
| else case <OG:Chloroplast> | |
| Identifier | EFTU |
| Protein name | RecName: Full=Elongation factor Tu, chloroplastic; Short=EF-Tu; |
| Gene name | Name=tufA; |
| end case | |
Comments
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| FUNCTION | This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. |
| case <OC:Bacteria> | |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OC:Archaea> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. |
Keywords
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| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Elongation factor | |
| Protein biosynthesis | |
| GTP-binding | |
| Nucleotide-binding | |
Gene Ontology
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| GO:0005525; Molecular function:GTP binding | |
| GO:0003746; Molecular function:translation elongation factor activity | |
| case <OCellular component:Bacteria> or <OC:Archaea> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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| Pfam | PF00009; GTP_EFTU; 1; |
| PRINTS | PR00315; ELONGATNFCT; 1; |
| NCBIfam | TIGR00483; EF-1_alpha; 1; |
| NCBIfam | TIGR00485; EF-Tu; 1; |
| PROSITE | PS00301; G_TR_1; 1; |
| PROSITE | PS51722; G_TR_2; 1; |
Features
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| From: EFTU1_ECOLI (P0CE47) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> or <OG:Chloroplast> | ||||||||||||
| BINDING | 19 | 26 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
G-[HQ]-[IV]-[DY]-H-G-K-[ST] | ||||||||
| BINDING | 81 | 85 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-x-P-G-H | ||||||||
| BINDING | 136 | 139 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
N-K-x-D | ||||||||
| end case | ||||||||||||
| From: EF1A_METJA (Q57770) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 14 | 21 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
G-H-[IV]-D-[NHA]-G-K-S | ||||||||
| BINDING | 91 | 95 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-x-P-G-H | ||||||||
| BINDING | 149 | 152 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
N-K-M-D | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 350-550 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Duplicated in some but not necessarily all Acidobacteriota, Pseudomonadota, Alkaliohilus, Clostrium, Chloroflexota, Deinococcus, Magnetococcus, Sphingobacter, Streptomyces, Syntrophobacter. Short versions in EHRRW, VIBVU, and a divergent copy in CHAGL are atypical. |