HAMAP rule MF_00118

General rule information [?]

Accession	MF_00118
Dates	1-JUN-2001 (Created) 17-FEB-2023 (Last updated, Version 45)

Name

EF_Tu

Scope

Bacteria

Archaea

Plastid

Templates

P35021 (EF1A_SACS2); P0CE47 (EFTU1_ECOLI); Q01698 (EFTU_THEAQ); P60338 (EFTU1_THETH); Q57770 (EF1A_METJA): [Recover all]

case <OC:Bacteria> or <OG:Chloroplast>

Triggered by

HAMAP; MF_00118_B (Get profile general information and statistics)

end case

case <OC:Archaea>

Triggered by

HAMAP; MF_00118_A (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria>

Identifier

EFTU

Protein name

RecName:		Full=Elongation factor Tu;
		Short=EF-Tu;

Gene name

tuf

else case <OC:Archaea>

Identifier

EF1A

Protein name

RecName:		Full=Elongation factor 1-alpha;
		Short=EF-1-alpha;
AltName:		Full=Elongation factor Tu;
		Short=EF-Tu;

Gene name

tuf

else case <OG:Chloroplast>

Identifier

EFTU

Protein name

RecName:		Full=Elongation factor Tu, chloroplastic;
		Short=EF-Tu;

Gene name

tufA

end case

Comments [?]

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

case <OC:Bacteria>

Subunit	Monomer.
Subcellular location	Cytoplasm.

end case

case <OC:Archaea>

Subcellular location

Cytoplasm.

end case

case <OG:Chloroplast>

Subcellular location

Plastid, chloroplast.

end case

Similarity

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

Keywords [?]

case not <OG:Chloroplast>

Cytoplasm

end case

Elongation factor
Protein biosynthesis
GTP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.

case <OC:Bacteria> or <OC:Archaea>

GO:0005737; Cellular component: cytoplasm.

end case

case <OG:Chloroplast>

GO:0009507; Cellular component: chloroplast.

end case

Cross-references [?]

Pfam	PF00009; GTP_EFTU; 1;
PRINTS	PR00315; ELONGATNFCT; 1;
TIGRFAMs	TIGR00483; EF-1_alpha; 1;
	TIGR00485; EF-Tu; 1;
PROSITE	PS00301; G_TR_1; 1;
	PS51722; G_TR_2; 1;

Features [?]

case <OC:Bacteria> or <OG:Chloroplast>

From: EFTU1_ECOLI (P0CE47)

Key From To Description Tag Condition FTGroup

BINDING 19 26 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 G-[HQ]-[IV]-[DY]-H-G-K-[ST]

BINDING 81 85 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 D-x-P-G-H

BINDING 136 139 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 N-K-x-D

end case

case <OC:Archaea>

From: EF1A_METJA (Q57770)

BINDING 14 21 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 G-H-[IV]-D-[NHA]-G-K-S

BINDING 91 95 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 D-x-P-G-H

BINDING 149 152 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 N-K-M-D

end case

Additional information [?]

Size range	350-550 amino acids
Related rules	None
Fusion	None
Comments	Duplicated in some but not necessarily all Acidobacteriota, Pseudomonadota, Alkaliohilus, Clostrium, Chloroflexota, Deinococcus, Magnetococcus, Sphingobacter, Streptomyces, Syntrophobacter. Short versions in EHRRW, VIBVU, and a divergent copy in CHAGL are atypical.

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