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HAMAP rule MF_00119

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General rule information [?]

Accession MF_00119
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 25)
Name eIF_2_gamma
Templates Q980A5 (IF2G_SACS2); Q8U082 (IF2G_PYRFU); Q9V1G0 (IF2G_PYRAB); O29663 (IF2G_ARCFU); Q58657 (IF2G_METJA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Translation initiation factor 2 subunit gamma;
AltName: Full=aIF2-gamma;
AltName: Full=eIF-2-gamma;
Gene name

Comments [?]

Function eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Catalytic activity RHEA:19669: GTP + H2O = GDP + H(+) + phosphate
Cofactor Mg(2+)
Subunit Heterotrimer composed of an alpha, a beta and a gamma chain.
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.

Cross-references [?]

Pfam PF09173; eIF2_C; 1;
PF00009; GTP_EFTU; 1;
NCBIfam TIGR03680; eif2g_arch; 1;
TIGR00231; small_GTP; 1;
PROSITE PS51722; G_TR_2; 1; trigger=PRU01059;

Features [?]

From: IF2G_SACS2 (Q980A5)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     19     24       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-H-G-K-[ST]-[ST]  
BINDING     149     152       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-[VI]-[DE]  
BINDING     184     186       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     S-A-x  
BINDING     19     19       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     23     23       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     [ST]  
BINDING     44     44       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     G  
BINDING     46     46       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     [ST]  
BINDING (Optional)     59     59       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING (Optional)     62     62       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING (Optional)     74     74       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING (Optional)     77     77       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 408-443 amino acids
Related rules None
Fusion None