HAMAP rule MF_00119
General rule information
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Accession | MF_00119 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 25) |
Name | eIF_2_gamma |
Scope | Archaea |
Templates | Q980A5 (IF2G_SACS2); Q8U082 (IF2G_PYRFU); Q9V1G0 (IF2G_PYRAB); O29663 (IF2G_ARCFU); Q58657 (IF2G_METJA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
|
Comments
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Function | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. |
Catalytic activity | RHEA:19669: GTP + H2O = GDP + H(+) + phosphate
EC 3.6.5.3 |
Cofactor | Mg(2+) |
Subunit | Heterotrimer composed of an alpha, a beta and a gamma chain. |
Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. |
Keywords
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Initiation factor
Protein biosynthesis
GTP-binding
Hydrolase
Nucleotide-binding
Metal-binding
Magnesium
Protein biosynthesis
GTP-binding
Hydrolase
Nucleotide-binding
Metal-binding
Magnesium
case <FTGroup:1>
end case
Gene Ontology
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GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0003746; Molecular function: translation elongation factor activity.
Cross-references
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Pfam | PF09173; eIF2_C; 1; |
PF00009; GTP_EFTU; 1; | |
NCBIfam | TIGR03680; eif2g_arch; 1; |
TIGR00231; small_GTP; 1; | |
PROSITE | PS51722; G_TR_2; 1; trigger=PRU01059; |
Features
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From: IF2G_SACS2 (Q980A5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 19 | 24 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-H-G-K-[ST]-[ST] | ||||||||
BINDING | 149 | 152 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-[VI]-[DE] | ||||||||
BINDING | 184 | 186 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | S-A-x | ||||||||
BINDING | 19 | 19 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | D | ||||||||
BINDING | 23 | 23 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | [ST] | ||||||||
BINDING | 44 | 44 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | G | ||||||||
BINDING | 46 | 46 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | [ST] | ||||||||
BINDING (Optional) | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 62 | 62 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 74 | 74 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING (Optional) | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 |
Additional information
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Size range | 408-443 amino acids |
Related rules | None |
Fusion | None |