HAMAP rule MF_00119

General rule information [?]

Accession	MF_00119
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 25)

Name	eIF_2_gamma

Scope

Archaea

Templates

Q980A5 (IF2G_SACS2); Q8U082 (IF2G_PYRFU); Q9V1G0 (IF2G_PYRAB); O29663 (IF2G_ARCFU); Q58657 (IF2G_METJA): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

IF2G

Protein name

RecName:		Full=Translation initiation factor 2 subunit gamma;
		EC 3.6.5.3;
AltName:		Full=aIF2-gamma;
AltName:		Full=eIF-2-gamma;

Gene name

eif2g

Comments [?]

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Catalytic activity	RHEA:19669: GTP + H2O = GDP + H(+) + phosphate EC 3.6.5.3
Cofactor	Mg(2+)
Subunit	Heterotrimer composed of an alpha, a beta and a gamma chain.
Similarity	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

Keywords [?]

case <FTGroup:1>

Zinc

end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.

Cross-references [?]

Features [?]

From: IF2G_SACS2 (Q980A5)

Key From To Description Tag Condition FTGroup

BINDING 19 24 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 D-H-G-K-[ST]-[ST]

BINDING 149 152 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 N-K-[VI]-[DE]

BINDING 184 186 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 S-A-x

BINDING 19 19 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 23 23 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 [ST]

BINDING 44 44 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 G

BINDING 46 46 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 [ST]

BINDING (Optional) 59 59 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 62 62 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 74 74 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING (Optional) 77 77 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

Additional information [?]