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HAMAP rule MF_00119
General rule information
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| Accession | MF_00119 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 25) |
| Name | eIF_2_gamma |
| Scope(s) |
Archaea |
| Template(s) | Q980A5 (IF2G_SACS2); Q8U082 (IF2G_PYRFU); Q9V1G0 (IF2G_PYRAB); O29663 (IF2G_ARCFU); Q58657 (IF2G_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00119 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | IF2G |
| Protein name | RecName: Full=Translation initiation factor 2 subunit gamma; EC=3.6.5.3; AltName: Full=aIF2-gamma; AltName: Full=eIF-2-gamma; |
| Gene name | Name=eif2g; |
Comments
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| FUNCTION | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Heterotrimer composed of an alpha, a beta and a gamma chain. |
| SIMILARITY | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. |
Keywords
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| Initiation factor | |
| Protein biosynthesis | |
| GTP-binding | |
| Hydrolase | |
| Nucleotide-binding | |
| Metal-binding | |
| Magnesium | |
| case <FTGroup:1> | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0005525; Molecular function:GTP binding |
| GO:0003746; Molecular function:translation elongation factor activity |
Cross-references
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| Pfam | PF09173; eIF2_C; 1; |
| Pfam | PF00009; GTP_EFTU; 1; |
| NCBIfam | TIGR03680; eif2g_arch; 1; |
| NCBIfam | TIGR00231; small_GTP; 1; |
| PROSITE | PS51722; G_TR_2; 1; |
Features
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| From: IF2G_SACS2 (Q980A5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 19 | 24 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-H-G-K-[ST]-[ST] | ||||||||
| BINDING | 149 | 152 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
N-K-[VI]-[DE] | ||||||||
| BINDING | 184 | 186 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
S-A-x | ||||||||
| BINDING | 19 | 19 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 23 | 23 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
[ST] | ||||||||
| BINDING | 44 | 44 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
G | ||||||||
| BINDING | 46 | 46 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
[ST] | ||||||||
| BINDING | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 62 | 62 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 74 | 74 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 408-443 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |