HAMAP rule MF_00121
General rule information
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Accession | MF_00121 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 28) |
Name | GatB |
Scope(s) |
Bacteria Archaea |
Template(s) | O30509 (GATB_BACSU); Q9LCX2 (GATB_THET8); O27341 (GATB_METTH); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00121 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | GATB |
Protein name | RecName: Full=Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Short=Asp/Glu-ADT subunit B; EC=6.3.5.-; |
Gene name | Name=gatB; |
Comments
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FUNCTION | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln). |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate; Xref=Rhea:RHEA:14513, Rhea:RHEA-COMP:9674, Rhea:RHEA-COMP:9677, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78515, ChEBI:CHEBI:78516, ChEBI:CHEBI:456216; |
SUBUNIT | Heterotrimer of A, B and C subunits. |
SIMILARITY | Belongs to the GatB/GatE family. GatB subfamily. |
Keywords
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Gene Ontology
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GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
GO:0006412; Biological process:translation |
Cross-references
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Pfam | PF02934; GatB_N; 1; |
Pfam | PF02637; GatB_Yqey; 1; |
NCBIfam | TIGR00133; GatB; 1; |
PROSITE | PS01234; GATB; 1; |
Features
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Additional information
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Size range | 449-517 amino acids |
Related rules |
MF_00588 |
Fusion | Nter: MF_00126 (glnS) Cter: None |