HAMAP rule MF_00122
General rule information
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Accession | MF_00122 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27) |
Name | GatC |
Scope(s) |
Bacteria Archaea |
Template(s) | O06492 (GATC_BACSU); Q9LCX4 (GATC_THET8); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00122 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | GATC |
Protein name | RecName: Full=Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Short=Asp/Glu-ADT subunit C; EC=6.3.5.-; |
Gene name | Name=gatC; |
Comments
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FUNCTION | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln). |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate; Xref=Rhea:RHEA:14513, Rhea:RHEA-COMP:9674, Rhea:RHEA-COMP:9677, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78515, ChEBI:CHEBI:78516, ChEBI:CHEBI:456216; |
SUBUNIT | Heterotrimer of A, B and C subunits. |
SIMILARITY | Belongs to the GatC family. |
Keywords
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Gene Ontology
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GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
GO:0006412; Biological process:translation |
Cross-references
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Features
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Additional information
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Size range | 89-104 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Not a very convincing alignment. Divergent BORBU, METJA and TREPA not shown in alignment. Divergent METTH (still in TrEMBL). Divergent and fused sequences in MYCGE, MYCPN (still in TrEMBL). |