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HAMAP rule MF_00122

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General rule information [?]

Accession MF_00122
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27)
Name GatC
Scope(s) Bacteria
Template(s) O06492 (GATC_BACSU); Q9LCX4 (GATC_THET8); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00122 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GATC
Protein name RecName: Full=Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C;
                 Short=Asp/Glu-ADT subunit C;
Gene name Name=gatC;

Comments [?]

FUNCTIONAllows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln).
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate; Xref=Rhea:RHEA:14513, Rhea:RHEA-COMP:9674, Rhea:RHEA-COMP:9677, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78515, ChEBI:CHEBI:78516, ChEBI:CHEBI:456216;
SUBUNITHeterotrimer of A, B and C subunits.
SIMILARITYBelongs to the GatC family.

Keywords [?]

Gene Ontology [?]

GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0006412; Biological process:translation

Cross-references [?]

Pfam PF02686; Glu-tRNAGln; 1;
NCBIfam TIGR00135; GatC; 1;

Features [?]

Additional information [?]

Size range 89-104 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Not a very convincing alignment. Divergent BORBU, METJA and TREPA not shown in alignment. Divergent METTH (still in TrEMBL). Divergent and fused sequences in MYCGE, MYCPN (still in TrEMBL).

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