HAMAP rule MF_00122

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00122
Accession	MF_00122
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 19)
Name	GatC
Scope(s)	Bacteria Archaea
Template(s)	O06492; Q9LCX4; [ Recover all ]
Triggered by	case c? <OC:Bacteria> or <OC:Archaea> HAMAP; MF_00122 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GATC
Protein name	RecName: Full=Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Short=Asp/Glu-ADT subunit C; EC=6.3.5.-;
Gene name	Name=gatC;

Comments [?]

FUNCTION	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln).
CATALYTIC ACTIVITY	Reaction=L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl- tRNA(Gln) + L-glutamate + ADP + phosphate + H(+); Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
CATALYTIC ACTIVITY	Reaction=L-aspartyl-tRNA(Asn) + L-glutamine + ATP + H2O = L- asparaginyl-tRNA(Asn) + L-glutamate + ADP + phosphate + 2 H(+); Xref=Rhea:RHEA:14513, Rhea:RHEA-COMP:9674, Rhea:RHEA-COMP:9677, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78515, ChEBI:CHEBI:78516, ChEBI:CHEBI:456216;
SUBUNIT	Heterotrimer of A, B and C subunits.
SIMILARITY	Belongs to the GatC family.

Keywords [?]

Gene Ontology [?]

GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

GO:0006412; Biological process:translation

Cross-references [?]

Pfam	PF02686; Glu-tRNAGln; 1;
NCBIfam	TIGR00135; GatC; 1;

Features [?]

Additional information [?]

Size range	89-104 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Not a very convincing alignment. Divergent BORBU, METJA and TREPA not shown in alignment. Divergent METTH (still in TrEMBL). Divergent and fused sequences in MYCGE, MYCPN (still in TrEMBL).