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HAMAP rule MF_00127

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General rule information [?]

Accession MF_00127
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 45)
Name His_tRNA_synth
Scope(s) Bacteria
Template(s) P60906 (SYH_ECOLI); P60911 (SYH_STAAU); P56194 (SYH_THET8); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
HAMAP; MF_00127 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SYH
case <OC:Bacteria> or <OC:Archaea>
Protein name RecName: Full=Histidine--tRNA ligase;
AltName: Full=Histidyl-tRNA synthetase;
else case <OG:Chloroplast>
Protein name RecName: Full=Histidine--tRNA ligase, chloroplastic;
AltName: Full=Histidyl-tRNA synthetase;
end case
Gene name Name=hisS;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665, Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442, ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=;
case <OC:Bacteria>
end case
case not <OG:Chloroplast>
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004821; Molecular function:histidine-tRNA ligase activity
GO:0006427; Biological process:histidyl-tRNA aminoacylation
case not <OG:Chloroplast>
GO:0005737; Cellular component:cytoplasm
end case
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
Pfam PF03129; HGTP_anticodon; 1;
NCBIfam TIGR00442; HisS; 1;

Features [?]

Additional information [?]

Size range 403-523 amino acids
Related rules MF_00125
Fusion Nter: None Cter: None
Comments Divergent TROW8 and TROWT; not shown in alignment. It is difficult to distinguish between hisS and hisZ families.

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