HAMAP rule MF_00127
General rule information
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| Accession | MF_00127 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 45) |
| Name | His_tRNA_synth |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P60906 (SYH_ECOLI); P60911 (SYH_STAAU); P56194 (SYH_THET8); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
HAMAP; MF_00127 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SYH |
| case <OC:Bacteria> or <OC:Archaea> | |
| Protein name | RecName: Full=Histidine--tRNA ligase; EC=6.1.1.21; AltName: Full=Histidyl-tRNA synthetase; Short=HisRS; |
| else case <OG:Chloroplast> | |
| Protein name | RecName: Full=Histidine--tRNA ligase, chloroplastic; EC=6.1.1.21; AltName: Full=Histidyl-tRNA synthetase; Short=HisRS; |
| end case | |
| Gene name | Name=hisS; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665, Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442, ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21; |
| case <OC:Bacteria> | |
| SUBUNIT | Homodimer. |
| end case | |
| case not <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Keywords
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| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Aminoacyl-tRNA synthetase | |
| Protein biosynthesis | |
| Ligase | |
| ATP-binding | |
| Nucleotide-binding | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0004821; Molecular function:histidine-tRNA ligase activity | |
| GO:0006427; Biological process:histidyl-tRNA aminoacylation | |
| case not <OG:Chloroplast> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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| Pfam | PF00587; tRNA-synt_2b; 1; |
| Pfam | PF03129; HGTP_anticodon; 1; |
| NCBIfam | TIGR00442; HisS; 1; |
| PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
Features
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Additional information
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| Size range | 403-523 amino acids |
| Related rules |
MF_00125 |
| Fusion | Nter: None Cter: None |
| Comments | Divergent TROW8 and TROWT; not shown in alignment. It is difficult to distinguish between hisS and hisZ families. |