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Annotation rule MF_00127
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General rule information [?]

Accession MF_00127
Dates 1-JUN-2001 (Created)
11-FEB-2022 (Last updated, Version 43)
Name His_tRNA_synth
Scope
Bacteria
Archaea
Plastid
Templates P60906 (SYH_ECOLI); P60911 (SYH_STAAU); P56194 (SYH_THET8): [Recover all]
case <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYH
case <OC:Bacteria> or <OC:Archaea>
Protein name
RecName: Full=Histidine--tRNA ligase;
EC 6.1.1.21;
AltName: Full=Histidyl-tRNA synthetase;
Short=HisRS;
else case <OG:Chloroplast>
Protein name
RecName: Full=Histidine--tRNA ligase, chloroplastic;
EC 6.1.1.21;
AltName: Full=Histidyl-tRNA synthetase;
Short=HisRS;
end case
Gene name
hisS

Comments [?]

Catalytic activity RHEA:17313: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
EC 6.1.1.21
case <OC:Bacteria>
Subunit Homodimer.
end case
case not <OG:Chloroplast>
Subcellular location Cytoplasm.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]

case not <OG:Chloroplast>
Cytoplasm
end case
Aminoacyl-tRNA synthetase
Protein biosynthesis
Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004821; Molecular function: histidine-tRNA ligase activity.
GO:0006427; Biological process: histidyl-tRNA aminoacylation.
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
PF03129; HGTP_anticodon; 1;
TIGRFAMs TIGR00442; HisS; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;

Additional information [?]

Size range 403-523 amino acids
Related rules MF_00125 (HISZ)
Fusion None
Comments Divergent TROW8 and TROWT; not shown in alignment. It is difficult to distinguish between hisS and hisZ families.


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