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HAMAP rule MF_00130

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General rule information [?]

Accession MF_00130
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name RecU
Scope(s) Bacteria
Template(s) P39792 (RECU_BACSU); Q5KXY4 (RECU_GEOKA); [ Recover all ]
Triggered by HAMAP; MF_00130 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RECU
Protein name RecName: Full=Holliday junction resolvase RecU;
AltName: Full=Recombination protein U homolog;
Gene name Name=recU;

Comments [?]

FUNCTIONEndonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
SIMILARITYBelongs to the RecU family.

Keywords [?]

Gene Ontology [?]

GO:0004519; Molecular function:endonuclease activity
GO:0000287; Molecular function:magnesium ion binding
GO:0007059; Biological process:chromosome segregation
GO:0006310; Biological process:DNA recombination
GO:0006281; Biological process:DNA repair
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03838; RecU; 1;
NCBIfam TIGR00648; RecU; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 84 84 /ligand="Mg(2+)"
BINDING 86 86 /ligand="Mg(2+)"
BINDING 99 99 /ligand="Mg(2+)"
BINDING 118 118 /ligand="Mg(2+)"
SITE 101 101 /note="Transition state stabilizer" K

Additional information [?]

Size range 157-213 amino acids
Related rules None
Fusion Nter: None Cter: None

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