HAMAP rule MF_00130
General rule information
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Accession | MF_00130 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 29) |
Name | RecU |
Scope | Bacteria |
Templates | P39792 (RECU_BACSU); Q5KXY4 (RECU_GEOKA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. |
Catalytic activity | Reaction=Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).; EC=3.1.21.10; |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the RecU family. |
Keywords
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Cytoplasm
DNA damage
DNA repair
DNA recombination
Endonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease
DNA damage
DNA repair
DNA recombination
Endonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease
Gene Ontology
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GO:0004519; Molecular function: endonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: RECU_GEOKA (Q5KXY4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 84 | 84 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | T | ||||||||
BINDING | 86 | 86 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 99 | 99 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [DE] | ||||||||
BINDING | 118 | 118 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | Q | ||||||||
SITE | 101 | 101 | Transition state stabilizer | K |
Additional information
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Size range | 157-213 amino acids |
Related rules | None |
Fusion | None |