HAMAP rule MF_00130

General rule information [?]

Accession	MF_00130
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 29)

Name

RecU

Scope

Bacteria

Templates

P39792 (RECU_BACSU); Q5KXY4 (RECU_GEOKA): [Recover all]

Triggered by

HAMAP; MF_00130 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RECU

Protein name

RecName:		Full=Holliday junction resolvase RecU;
		EC 3.1.21.10;
AltName:		Full=Recombination protein U homolog;

Gene name

recU

Comments [?]

Function	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.
Catalytic activity	Reaction=Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).; EC=3.1.21.10;
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
Subcellular location	Cytoplasm.
Similarity	Belongs to the RecU family.

Keywords [?]

Cytoplasm
DNA damage
DNA repair
DNA recombination
Endonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF03838; RecU; 1;
TIGRFAMs	TIGR00648; RecU; 1;

Features [?]

From: RECU_GEOKA (Q5KXY4)

Key From To Description Tag Condition FTGroup

BINDING 84 84 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 T

BINDING 86 86 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 99 99 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [DE]

BINDING 118 118 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 Q

SITE 101 101 Transition state stabilizer K

Additional information [?]

Size range	157-213 amino acids
Related rules	None
Fusion	None

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