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HAMAP rule MF_00130

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General rule information [?]

Accession MF_00130
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 29)
Name RecU
Templates P39792 (RECU_BACSU); Q5KXY4 (RECU_GEOKA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Holliday junction resolvase RecU;
AltName: Full=Recombination protein U homolog;
Gene name

Comments [?]

Function Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.
Catalytic activity Reaction=Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).; EC=;
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
Subcellular location Cytoplasm.
Similarity Belongs to the RecU family.

Keywords [?]

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03838; RecU; 1;
TIGRFAMs TIGR00648; RecU; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     84     84       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     T  
BINDING     86     86       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     99     99       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [DE]  
BINDING     118     118       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     Q  
SITE     101     101       Transition state stabilizer     K  

Additional information [?]

Size range 157-213 amino acids
Related rules None
Fusion None